1. Stem Cell/Wnt
  2. YAP
  3. TEAD-IN-10

TEAD-IN-10 (compound 15) has good selective activity and inhibitory effect on TEAD1 (IC50=14 nM), TEAD2 (IC50=179 nM) and TEAD3 (IC50=4 nnM) as a covalent inhibitor. TEAD-IN-10 can be used for cancer research.

For research use only. We do not sell to patients.

TEAD-IN-10 Chemical Structure

TEAD-IN-10 Chemical Structure

CAS No. : 3032196-65-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TEAD-IN-10 (compound 15) has good selective activity and inhibitory effect on TEAD1 (IC50=14 nM), TEAD2 (IC50=179 nM) and TEAD3 (IC50=4 nnM) as a covalent inhibitor. TEAD-IN-10 can be used for cancer research[1].

IC50 & Target[1]

TAED1

14 nM (IC50)

TAED2

179 nM (IC50)

TAED3

4 nM (IC50)

In Vitro

TEAD-IN-10 has a great inhibition for MCF-7 reporter assay (IC50≤10 nM)[1].
TEAD-IN-10 has a great selectivity for TEAD1 and TEAD2 with 97% and 98% inhibition in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NCl-H226 and H2052 cell lines
Concentration:
Incubation Time: 6 days
Result: The inhibitory effect of H2052 cell line (IC50≤100 nM) was better than that of NCl-H226 cell line (IC50:100-500 nM).

Cell Proliferation Assay[1]

Cell Line: NCl-H226 and H2052 cell lines
Concentration:
Incubation Time: 7 days
Result: The inhibition rate of anti-proliferation of both cell lines was greater than 75%.
Molecular Weight

281.27

Formula

C15H14F3NO

CAS No.
SMILES

O=C(C=C)N(C1)CC1/C=C/C2=CC=C(C(F)(F)F)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TEAD-IN-10
Cat. No.:
HY-161568
Quantity:
MCE Japan Authorized Agent: