2. Stem Cell/Wnt
  3. YAP
  4. TEAD-IN-10

TEAD-IN-10 (compound 15) has good selective activity and inhibitory effect on TEAD1 (IC50=14 nM), TEAD2 (IC50=179 nM) and TEAD3 (IC50=4 nnM) as a covalent inhibitor. TEAD-IN-10 can be used for cancer research.

For research use only. We do not sell to patients.

TEAD-IN-10 Chemical Structure

TEAD-IN-10 Chemical Structure

CAS No. : 3032196-65-6

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TEAD-IN-10 Related Antibodies

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Description

TEAD-IN-10 (compound 15) has good selective activity and inhibitory effect on TEAD1 (IC50=14 nM), TEAD2 (IC50=179 nM) and TEAD3 (IC50=4 nnM) as a covalent inhibitor. TEAD-IN-10 can be used for cancer research[1].

IC50 & Target[1]

TAED1

14 nM (IC50)

TAED2

179 nM (IC50)

TAED3

4 nM (IC50)

In Vitro

TEAD-IN-10 has a great inhibition for MCF-7 reporter assay (IC50≤10 nM)[1].
TEAD-IN-10 has a great selectivity for TEAD1 and TEAD2 with 97% and 98% inhibition in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TEAD-IN-10 Related Antibodies

Cell Viability Assay[1]

Cell Line: NCl-H226 and H2052 cell lines
Concentration:
Incubation Time: 6 days
Result: The inhibitory effect of H2052 cell line (IC50≤100 nM) was better than that of NCl-H226 cell line (IC50:100-500 nM).

Cell Proliferation Assay[1]

Cell Line: NCl-H226 and H2052 cell lines
Concentration:
Incubation Time: 7 days
Result: The inhibition rate of anti-proliferation of both cell lines was greater than 75%.
Molecular Weight

281.27

Formula

C15H14F3NO
CAS No.
SMILES

O=C(C=C)N(C1)CC1/C=C/C2=CC=C(C(F)(F)F)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TEAD-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TEAD-IN-103032196-65-6YAPYes-associated proteinTEADcovalent inhibitordrughunterNCl-H226 and H2052 cell linesInhibitorinhibitorinhibit

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