Ppp1r9b - protein phosphatase 1, regulatory subunit 9B Gene

Rattus norvegicus

Also known as Neb2

Gene ID: 84686 | Gene type: protein coding

About Ppp1r9b

Summary

Enables several functions, including D2 Dopamine Receptor binding activity; Enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; pallium development; and positive regulation of protein localization to cell periphery. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Biomarker of Parkinson's disease. Orthologous to human PPP1R9B (protein Phosphatase 1 regulatory subunit 9B). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r9b Products(2)

mRNA	Protein	Name
NM_053474.2	NP_445926.1	neurabin-2
NM_053474.2	NP_445926.1	neurabin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D2 dopamine receptor binding	IPI IPI: Inferred from physical interaction	10391935	RGD
enables actin binding	IDA IDA: Inferred from direct assay	15135218	RGD
enables actin filament binding	IDA IDA: Inferred from direct assay	12417592	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	11182094	RGD
enables nucleic acid binding	EXP EXP: Inferred from Experiment	18028445	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9514910	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	9653190	RGD
enables protein phosphatase 1 binding	IDA IDA: Inferred from direct assay	9275233	RGD
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	12016225	RGD
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	12016225	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12270929	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16025302	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament depolymerization	IEP IEP: Inferred from expression pattern	10620493	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	10620493	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	16951259	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16951259	RGD
involved in cellular response to peptide	IEP IEP: Inferred from expression pattern	21123436	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16844384	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	9275233	RGD
involved in developmental process involved in reproduction	IEP IEP: Inferred from expression pattern	18096161	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	21123436	RGD
involved in learning	IEP IEP: Inferred from expression pattern	24069387	RGD
involved in male mating behavior	IEP IEP: Inferred from expression pattern	18726914	RGD
involved in positive regulation of protein localization	IDA IDA: Inferred from direct assay	18216290	RGD
involved in positive regulation of protein localization to actin cortical patch	IMP IMP: Inferred from mutant phenotype	18216290	RGD
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	9514910	RGD
involved in protein localization to actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	18216290	RGD
involved in protein localization to cell periphery	IMP IMP: Inferred from mutant phenotype	18216290	RGD
involved in reproductive system development	IEP IEP: Inferred from expression pattern	18096161	RGD
involved in response to L-phenylalanine derivative	IEP IEP: Inferred from expression pattern	12112407	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17443789	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	19932152	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17443789	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	22128856	RGD
involved in response to kainic acid	IEP IEP: Inferred from expression pattern	17443789	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	22959963	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17408863	RGD
involved in response to prostaglandin E	IEP IEP: Inferred from expression pattern	23054057	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	20399784	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	22160164	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10514494	RGD
located in cytoplasmic side of dendritic spine plasma membrane	IDA IDA: Inferred from direct assay	9275233	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	15135218	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	9275233	RGD
located in dendritic spine membrane	IDA IDA: Inferred from direct assay	9275233	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	9275233	RGD
is active in extrinsic component of postsynaptic membrane	IDA IDA: Inferred from direct assay	9275233	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9275233	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12270929	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10620493	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	9275233	RGD
is active in spine apparatus	IDA IDA: Inferred from direct assay	9275233	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurabin-2

PP1bp134	neurabin-II
neural tissue-specific F-actin-binding protein II	nuerabin 2
p130	spinophilin

Ppp1r9b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ppp1r9b	O35274	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	25785436
Cross	Ppp1r9b	O35274	PTPN6	Homo sapiens	P29350	Anti Tag CoIP	25785436
Intra	Ppp1r9b	O35274	Drd2	Rattus norvegicus	P61169	Y2H	10391935
Intra	Ppp1r9b	O35274	Ppp1cc	Rattus norvegicus	P63088	Pull Down	10391935
Intra	Ppp1r9b	O35274	Ppp1cc	Rattus norvegicus	P63088	Imaging	18216290

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11006	PPP1R9B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1r9b	NCBI	NCBI:84687

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