RAE1 - ribonucleic acid export 1 Gene

Homo sapiens

Also known as Gle2; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1

Gene ID: 8480 | Gene type: protein coding

About RAE1

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,351,255-57,379,202 (from NCBI)

This gene has 9 transcripts (splice variants), 216 orthologues and 2 paralogues. Broad expression in testis (RPKM 35.7), bone marrow (RPKM 13.2) and 24 other tissues.

Summary

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the Cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RAE1 Products(2)

mRNA	Protein	Name
NM_001015885.2	NP_001015885.1	mRNA export factor RAE1
NM_003610.4	NP_003601.1	mRNA export factor RAE1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	9256445	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17172455	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	17172455	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitotic spindle pole	IMP IMP: Inferred from mutant phenotype	17172455	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	9256445	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	9256445	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAE1 Protein Structure

WD40

0
100
200
300
368 a.a.

Protein Preferred Names

Protein Names

mRNA export factor RAE1

RAE1 RNA export 1 homolog

RAE1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	RAE1	P78406	ns6_sars2	SARS-CoV-2	P0DTC6	Y2H Array	36217030
Intra	RAE1	P78406	NUP98	Homo sapiens	P52948	Anti Bait CoIP	18832153
Intra	RAE1	P78406	NUP98	Homo sapiens	P52948	Anti Bait CoIP	17172455
Intra	RAE1	P78406	NUP98	Homo sapiens	P52948	Anti Tag CoIP	33961781
Intra	RAE1	P78406	NUMA1	Homo sapiens	Q14980	Pull Down	17172455
Intra	RAE1	P78406	NUMA1	Homo sapiens	Q14980	Anti Bait CoIP	17172455
Intra	RAE1	P78406	NUMA1	Homo sapiens	Q14980	Anti Tag CoIP	17172455
Intra	RAE1	P78406	SMC1A	Homo sapiens	Q14683	Anti Bait CoIP	18832153

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lethal Congenital Contracture Syndrome 1

LCCS1	Multiple Contracture Syndrome, Finnish Type
Lccs	Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures
Lethal Congenital Contracture Syndrome Type 1	Herva Disease
Multiple Contracture Syndrome Finnish Type	Contracture Syndrome, Lethal, Congenital, Type 1

Lethal Congenital Contracture Syndrome

Lccs	Lethal Congenital Contracture Syndrome 1

Anterior Horn Cell Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11617	RAE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAE1	VGNC	VGNC:33692
Mus musculus	RAE1	MGD	MGI:1913929
Felis catus	RAE1	VGNC	VGNC:69219
Canis familiaris	RAE1	VGNC	VGNC:45324
Macaca mulatta	RAE1	VGNC	VGNC:82216
Rattus norvegicus	RAE1	RGD	RGD:1311540

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