PTPN5 - protein tyrosine phosphatase non-receptor type 5 Gene

Homo sapiens

Also known as STEP; STEP61; PTPSTEP

Gene ID: 84867 | Gene type: protein coding

About PTPN5

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,727,928-18,792,721 (from NCBI)

This gene has 6 transcripts (splice variants), 202 orthologues and 35 paralogues. Biased expression in brain (RPKM 11.0), testis (RPKM 0.9) and 1 other tissue.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be integral component of membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

PTPN5 Products(6)

mRNA	Protein	Name
NM_001039970.2	NP_001035059.1	tyrosine-protein phosphatase non-receptor type 5 isoform b
NM_001278236.1	NP_001265165.1	tyrosine-protein phosphatase non-receptor type 5 isoform b
NM_001278238.2	NP_001265167.1	tyrosine-protein phosphatase non-receptor type 5 isoform c
NM_001278239.2	NP_001265168.1	tyrosine-protein phosphatase non-receptor type 5 isoform d
NM_006906.2	NP_008837.1	tyrosine-protein phosphatase non-receptor type 5 isoform a
NM_032781.4	NP_116170.3	tyrosine-protein phosphatase non-receptor type 5 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphotyrosine residue binding	IDA IDA: Inferred from direct assay	16441242	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN5 Protein Structure

Y_phosphatase

0
100
200
300
400
500
565 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 5

neural-specific protein-tyrosine phosphatase

PTPN5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN5	P54829	TMEM201	Homo sapiens	Q5SNT2-2	Validated Y2H	32296183
Intra	PTPN5	P54829	SLC35B1	Homo sapiens	P78383	Validated Y2H	32296183
Intra	PTPN5	P54829	CLEC4G	Homo sapiens	Q6UXB4	Validated Y2H	32296183
Intra	PTPN5	P54829	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	PTPN5	P54829	CXCL9	Homo sapiens	Q07325	Y2H Prey Pooling	25416956
Intra	PTPN5	P54829	CXCL9	Homo sapiens	Q07325	Validated Y2H	25416956
Intra	PTPN5	P54829	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	PTPN5	P54829	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	PTPN5	P54829	VTI1B	Homo sapiens	Q9UEU0	Y2H Array	31515488
Intra	PTPN5	P54829	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	25416956
Intra	PTPN5	P54829	TMEM51	Homo sapiens	Q9NW97	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Viral Gastritis

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Phencyclidine Abuse

Pcp Abuse

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141800	MurA-IN-1	Inhibitor	99.32%	Unkown
HY-RS11428	PTPN5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTPN5	RGD	RGD:3448
Macaca mulatta	PTPN5	VGNC	VGNC:76606
Canis familiaris	PTPN5	VGNC	VGNC:45178
Felis catus	PTPN5	VGNC	VGNC:69165
Mus musculus	PTPN5	MGD	MGI:97807
Bos taurus	PTPN5	VGNC	VGNC:33540

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