2. Gene
  3. SLC35B1 - solute carrier family 35 member B1 Gene

SLC35B1 - solute carrier family 35 member B1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AXER; UGTREL1

Gene ID: 10237 | Gene type: protein coding

About SLC35B1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,700,943-49,708,197 (from NCBI)

This gene has 20 transcripts (splice variants), 203 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 24.3), duodenum (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

SLC35B1 Products(2)

mRNA Protein Name
NM_001278784.2 NP_001265713.1 solute carrier family 35 member B1 isoform 2
NM_005827.4 NP_005818.3 solute carrier family 35 member B1 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP:ADP antiporter activity IDA
IDA: Inferred from direct assay
30154480 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30154480 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35B1 Protein Structure

UAA

UAA: UAA transporter family (16 - 315)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
Protein Preferred Names Protein Names

solute carrier family 35 member B1

ATP/ADP exchanger ER

SLC35B1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC35B1 P78383 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra
SLC35B1 P78383 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
SLC35B1 P78383 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
SLC35B1 P78383 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
SLC35B1 P78383 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
SLC35B1 P78383 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
Intra
SLC35B1 P78383 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
Intra
SLC35B1 P78383 PTPN5 Homo sapiens P54829
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 PTPN5 Homo sapiens P54829
Y2H Array
32296183
Intra
SLC35B1 P78383 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
SLC35B1 P78383 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
SLC35B1 P78383 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SLC35B1 P78383 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
SLC35B1 P78383 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
SLC35B1 P78383 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 FZD5 Homo sapiens Q13467
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 FZD5 Homo sapiens Q13467
Validated Y2H
32296183
Intra
SLC35B1 P78383 FZD5 Homo sapiens Q13467
Y2H Array
32296183
Intra
SLC35B1 P78383 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SLC35B1 P78383 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SLC35B1 P78383 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra
SLC35B1 P78383 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
SLC35B1 P78383 FKBP8 Homo sapiens Q14318
Validated Y2H
32296183
Intra
SLC35B1 P78383 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
Intra
SLC35B1 P78383 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
Intra
SLC35B1 P78383 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Intra
SLC35B1 P78383 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
SLC35B1 P78383 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 CCDC107 Homo sapiens Q8WV48
Y2H Prey Pooling
32296183
Intra
SLC35B1 P78383 CCDC107 Homo sapiens Q8WV48
Validated Y2H
32296183
Intra
SLC35B1 P78383 CCDC107 Homo sapiens Q8WV48
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome
Dicarboxylic Aminoaciduria

Glutamate-Aspartate Transport Defect

Dicarboxylicaminoaciduria

DCBXA

Renal Aminoacidurias
Bardet-Biedl Syndrome 10

BBS10

Bardet-Biedl Syndrome

Bbs

Bardet-Biedl Syndrome, Type 10
Hydranencephaly

Hydroanencephaly
Chromosome 1q21.1 Deletion Syndrome, 1.35-Mb

Chromosome 1q21.1 Deletion Syndrome

1q21.1 Microdeletion Syndrome

Monosomy 1q21.1

1q21.1 Microdeletion

Chromosome 1q21.1 Microdeletion Syndrome

1q21.1 Contiguous Gene Deletion

1q21.1 Deletion

Del(1)(Q21)

1q21.1 Deletion Syndrome
Retinitis Pigmentosa 12

RP12

Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

Rp With Or Without Pprpe

Retinitis Pigmentosa-12
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13198 SLC35B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC35B1 MGD MGI:1343133
Rattus norvegicus SLC35B1 RGD RGD:727783
Macaca mulatta SLC35B1 VGNC VGNC:77533
Canis familiaris SLC35B1 VGNC VGNC:46364
Bos taurus SLC35B1 VGNC VGNC:34823
Felis catus SLC35B1 VGNC VGNC:65324