2. Gene
  3. CBX4 - chromobox 4 Gene

CBX4 - chromobox 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PC2; NBP16

Gene ID: 8535 | Gene type: protein coding

About CBX4

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,833,156-79,839,440 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 8 paralogues. Broad expression in bone marrow (RPKM 17.4), spleen (RPKM 5.9) and 24 other tissues.

Summary

Enables SUMO binding activity; SUMO Ligase activity; and Enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

CBX4 Products(1)

mRNA Protein Name
NM_003655.3 NP_003646.2 E3 SUMO-protein ligase CBX4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SUMO binding IDA
IDA: Inferred from direct assay
20176810 GOA
enables SUMO ligase activity IDA
IDA: Inferred from direct assay
27068747 GOA
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
12679040 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
17087506 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18567530 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21282530 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PRC1 complex IDA
IDA: Inferred from direct assay
12167701 GOA
part of PcG protein complex IDA
IDA: Inferred from direct assay
21282530 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9367786 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBX4 Protein Structure

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (11 - 60)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 560 a.a.
Protein Preferred Names Protein Names

E3 SUMO-protein ligase CBX4

NS5ATP1-binding protein 16

CBX4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CBX4 O00257 BMI1 Homo sapiens P35226
Anti Tag CoIP
26496610
Intra
CBX4 O00257 BMI1 Homo sapiens P35226
TAP
27705803
Intra
CBX4 O00257 BMI1 Homo sapiens P35226
Anti Bait CoIP
22078878
Intra
CBX4 O00257 YWHAB Homo sapiens P31946
Anti Bait CoIP
22078878
Intra
CBX4 O00257 HIF1A Homo sapiens Q16665
Anti Tag CoIP
24434214
Intra
CBX4 O00257 HIF1A Homo sapiens Q16665
CH-IP
24434214
Intra
CBX4 O00257 HIF1A Homo sapiens Q16665
Pull Down
24434214
Intra
CBX4 O00257 CBX8 Homo sapiens Q9HC52
Anti Bait CoIP
17332741
Intra
CBX4 O00257 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
26496610
Intra
CBX4 O00257 RNF2 Homo sapiens Q99496
TAP
27705803
Intra
CBX4 O00257 RNF2 Homo sapiens Q99496
Anti Tag CoIP
26496610
Intra
CBX4 O00257 SUMO1 Homo sapiens P63165
Confocal
20098713
Intra
CBX4 O00257 SUMO1 Homo sapiens P63165
Pull Down
20098713
Intra
CBX4 O00257 CTBP1 Homo sapiens Q13363
Anti Tag CoIP
20098713
Intra
CBX4 O00257 CTBP1 Homo sapiens Q13363
Confocal
20098713
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02011 CBX4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CBX4 RGD RGD:1587243
Canis familiaris CBX4 VGNC VGNC:54929
Macaca mulatta CBX4 VGNC VGNC:70558
Mus musculus CBX4 MGD MGI:1195985
Felis catus CBX4 VGNC VGNC:98768
Bos taurus CBX4 VGNC VGNC:55784