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  2. MAPKAPK5 - MAPK activated protein kinase 5 Gene

MAPKAPK5 - MAPK activated protein kinase 5 Gene

Homo sapiens

Also known as MK5; MK-5; NCFD; PRAK; MAPKAP-K5

Gene ID: 8550 | Gene type: protein coding

About MAPKAPK5

Cytogenetic location: 12q24.12-q24.13 Genomic coordinates (GRCh38): 12:111,842,228-111,902,222 (from NCBI)

This gene has 10 transcripts (splice variants), 178 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 3.1), colon (RPKM 2.9) and 25 other tissues.

Summary

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

MAPKAPK5 Products(11)

mRNA Protein Name
NM_001371479.1 NP_001358408.1 MAP kinase-activated protein kinase 5 isoform 3
NM_001371480.1 NP_001358409.1 MAP kinase-activated protein kinase 5 isoform 4
NM_001371481.1 NP_001358410.1 MAP kinase-activated protein kinase 5 isoform 5
NM_001371482.1 NP_001358411.1 MAP kinase-activated protein kinase 5 isoform 6
NM_001371483.1 NP_001358412.1 MAP kinase-activated protein kinase 5 isoform 7
NM_001371484.1 NP_001358413.1 MAP kinase-activated protein kinase 5 isoform 8
NM_001371485.1 NP_001358414.1 MAP kinase-activated protein kinase 5 isoform 9
NM_001371486.1 NP_001358415.1 MAP kinase-activated protein kinase 5 isoform 10
NM_001371487.1 NP_001358416.1 MAP kinase-activated protein kinase 5 isoform 11
NM_003668.4 NP_003659.2 MAP kinase-activated protein kinase 5 isoform 1
NM_139078.3 NP_620777.1 MAP kinase-activated protein kinase 5 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables p53 binding IDA
IDA: Inferred from direct assay
17254968 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17254968 GOA
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
17254968 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
17254968 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Ras protein signal transduction IDA
IDA: Inferred from direct assay
17254968 GOA
acts upstream of positive regulation of telomere maintenance IMP
IMP: Inferred from mutant phenotype
21531765 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21531765 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
21329882 GOA
involved in regulation of translation IDA
IDA: Inferred from direct assay
21329882 GOA
involved in stress-induced premature senescence IDA
IDA: Inferred from direct assay
17254968 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPKAPK5 Protein Structure

Pkinase

Pkinase: Protein kinase domain (25 - 304)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

MAP kinase-activated protein kinase 5

MAPKAP kinase 5

MAPKAPK5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659 25416956
Intra
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659 33961781
Intra
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659 32707033
Intra
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659
Y2H
21900206
Intra
MAPKAPK5 Q8IW41 MAPK6 Homo sapiens Q16659 20936779
Intra
MAPKAPK5 Q8IW41 HSPB1 Homo sapiens P04792 21575178
Intra
MAPKAPK5 Q8IW41 TP53 Homo sapiens P04637 17254968
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPKAPK5 Proteins

Cat. No. Product Name Accession Purity
HY-P74621 PRAK/MAPKAPK5 Protein, Human (sf9, His-GST) Q8IW41-2/NP_003659.2 (M1-Q471) ≥95%

Related Diseases

Diseases Alias
Neurocardiofaciodigital Syndrome

NCFD

Dientamoebiasis

Intestinal Trichomoniasis

Glioblastoma Mesenchymal Subtype
Pulmonary Immaturity

Primary Atelectasis Of Newborn

Primary Atelectasis, In Perinatal Period

Primary Failure To Expand Terminal Respiratory Units

Immature Lungs

Primary Atelectasis

Pulmonary Immaturity Nos

Lung Lobe Hypoplasia, Associated With Short Gestation

Lung Nonexpansion

Premature Lungs

Pulmonary Hypoplasia Associated With Short Gestation

Failure Of Expansion Of Terminal Respiratory Units

Primary Atelectasis Of Fetus Or Newborn

Primary Atelectasis In Perinatal Period

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus MAPKAPK5 VGNC VGNC:31230
Rattus norvegicus MAPKAPK5 RGD RGD:1564113
Mus musculus MAPKAPK5 MGD MGI:1333110
Canis familiaris MAPKAPK5 VGNC VGNC:43008
Felis catus MAPKAPK5 VGNC VGNC:68177
Macaca mulatta MAPKAPK5 VGNC VGNC:74655
Others MAPKAPK5 NCBI