AKR1C3 - aldo-keto reductase family 1 member C3 Gene

Homo sapiens

Also known as DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS

Gene ID: 8644 | Gene type: protein coding

About AKR1C3

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,048,781-5,107,686 (from NCBI)

This gene has 11 transcripts (splice variants), 481 orthologues and 16 paralogues. Broad expression in duodenum (RPKM 122.7), gall bladder (RPKM 91.1) and 15 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. These Enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The Enzymes display overlapping but distinct substrate specificity. This Enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three Other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

AKR1C3 Products(3)

mRNA	Protein	Name
NM_001253908.2	NP_001240837.1	aldo-keto reductase family 1 member C3 isoform 2
NM_001253909.2	NP_001240838.1	aldo-keto reductase family 1 member C3 isoform 3
NM_003739.6	NP_003730.4	aldo-keto reductase family 1 member C3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	22170488	GOA
enables Delta4-3-oxosteroid 5beta-reductase activity	IDA IDA: Inferred from direct assay	16983398	GOA
enables aldo-keto reductase (NADPH) activity	IDA IDA: Inferred from direct assay	9792917	GOA
enables aldose reductase (NADPH) activity	IDA IDA: Inferred from direct assay	21232532	GOA
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	21851338	GOA
enables androsterone dehydrogenase activity	IDA IDA: Inferred from direct assay	16983398	GOA
enables geranylgeranyl reductase activity	IDA IDA: Inferred from direct assay	21187079	GOA
enables ketoreductase activity	IDA IDA: Inferred from direct assay	19487289	GOA
enables ketosteroid monooxygenase activity	IDA IDA: Inferred from direct assay	21232532	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: Inferred from direct assay	19442656	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables retinal dehydrogenase activity	IDA IDA: Inferred from direct assay	21851338	GOA
enables testosterone dehydrogenase [NAD(P)+] activity	IDA IDA: Inferred from direct assay	16983398	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18508192	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	22170488	GOA
involved in cellular response to corticosteroid stimulus	IDA IDA: Inferred from direct assay	19336506	GOA
involved in cellular response to jasmonic acid stimulus	IDA IDA: Inferred from direct assay	19487289	GOA
involved in cellular response to prostaglandin D stimulus	IDA IDA: Inferred from direct assay	18508192	GOA
involved in cellular response to prostaglandin stimulus	IDA IDA: Inferred from direct assay	22170488	GOA
involved in cellular response to starvation	IEP IEP: Inferred from expression pattern	18641923	GOA
involved in daunorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in doxorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in farnesol catabolic process	IDA IDA: Inferred from direct assay	21187079	GOA
involved in keratinocyte differentiation	IEP IEP: Inferred from expression pattern	22170488	GOA
involved in macromolecule metabolic process	IEP IEP: Inferred from expression pattern	18641923	GOA
involved in male gonad development	IEP IEP: Inferred from expression pattern	19942269	GOA
involved in negative regulation of retinoic acid biosynthetic process	IDA IDA: Inferred from direct assay	21851338	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18508192	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21851338	GOA
involved in positive regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	19442656	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	18508192	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19442656	GOA
involved in progesterone metabolic process	IDA IDA: Inferred from direct assay	21232532	GOA
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	9792917	GOA
involved in prostaglandin metabolic process	IEP IEP: Inferred from expression pattern	20036328	GOA
involved in regulation of retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	21851338	GOA
involved in regulation of testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	19336506	GOA
involved in response to nutrient	IEP IEP: Inferred from expression pattern	19007764	GOA
involved in retinal metabolic process	IDA IDA: Inferred from direct assay	21851338	GOA
involved in steroid metabolic process	IEP IEP: Inferred from expression pattern	20036328	GOA
involved in testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	16983398	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18574251	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18574251	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1C3 Protein Structure

Aldo_ket_red

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

aldo-keto reductase family 1 member C3

3-alpha hydroxysteroid dehydrogenase, type II

AKR1C3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKR1C3	P42330	AKR1C4	Homo sapiens	P17516	Anti Tag CoIP	33961781
Intra	AKR1C3	P42330	AKR1C4	Homo sapiens	P17516	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AKR1C3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7604	AKR1C3 Protein, Human (HEK293, His)	P42330 (M1-S323)	≥95%

Related Diseases

Diseases

Alias

Larynx Squamous Papilloma

Laryngeal Squamous Cell Papilloma

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

17-Beta Hydroxysteroid Dehydrogenase Iii Deficiency

17-Ksr Deficiency	Neutral 17-Beta-Hydroxysteroid Oxidoreductase Deficiency
Pseudohermaphroditism, Male, With Gynecomastia	17-Beta Hydroxysteroid Dehydrogenase 3 Deficiency
Testosterone 17-Beta-Dehydrogenase Deficiency	17-Ketosteroid Reductase Deficiency Of Testis
17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency	17-Ketoreductase Deficiency
17-Ketosteroidreductase Deficiency	46,Xy Disorder Of Sex Development Due To 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency
Male Pseudohermaphroditism With Gynecomastia	17 Alpha Ksr Deficiency
17 Alpha Ketosteroid Reductase Deficiency Of Testis	17 Beta Hydroxysteroid Dehydrogenase Iii Deficiency
Male Pseudoherma-Phroditism With Gynecomastia	Neutral 17 Beta Hydroxysteroid Oxidoreductase Deficiency
Male Pseudohermaphrodism With Gynecomastia	MPH
17-Hydroxysteroid Dehydrogenase Deficiency

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19903	ASP-9521	Inhibitor	≥98.0%	Phase 2
HY-124573	OBI-3424		99.23%	Phase 2

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0376	Liquiritin		99.68%	Unkown
HY-138557	AKR1C3-IN-4	Inhibitor	99.77%	Unkown
HY-150644	S07-2010	Inhibitor	99.79%	Unkown
HY-107379	AKR1C3-IN-1	Inhibitor	98.23%	Unkown
HY-N10361	Drupanin		98.05%	Unkown
HY-155035	S07-1066	Inhibitor	99.48%	Unkown
HY-D1342	Coumberol		99.99%	Unkown
HY-152189	S19-1035		99.77%	Unkown
HY-152188	AKR1C3-IN-9	Inhibitor	99.37%	Unkown
HY-109154	Obafistat	Inhibitor	99.92%	Unkown
HY-116170	SN34037		/	Unkown
HY-121656	AKR1C2/3-IN-2		/	Unkown
HY-144749	AKR1C3-IN-5	Inhibitor	/	Unkown
HY-146573	AKR1C3-IN-6	Inhibitor	/	Unkown
HY-146574	AKR1C3-IN-7	Inhibitor	/	Unkown
HY-146575	AKR1C3-IN-8	Inhibitor	/	Unkown
HY-150646	S07-2009		/	Unkown
HY-150648	S07-2008	Inhibitor	/	Unkown
HY-150649	S07-2005 (racemic)		/	Unkown
HY-150650	S07-2001		/	Unkown
HY-155502	AKR1C3-IN-10	Inhibitor	/	Unkown
HY-157810	AKR1C3-IN-11	Inhibitor	/	Unkown
HY-161839	AKR1C2/3-IN-1	Inhibitor	/	Unkown
HY-163323	AKR1C3-IN-12	Inhibitor	/	Unkown
HY-163609	PROTAC AKR1C3 degrader-1	Degrader	/	Unkown
HY-163610	AKR1C3-IN-13	Inhibitor	/	Unkown
HY-163784	AKR1C3-IN-14	Inhibitor	/	Unkown
HY-163940	LX1	Inhibitor	/	Unkown
HY-N0376R	Liquiritin (Standard)		/	Unkown
HY-RS00536	AKR1C3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-163647	Lenalidomide-COCH-PEG2-azido		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKR1C3	RGD	RGD:708428
Others	AKR1C3	NCBI

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