LAMTOR3 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Gene

Homo sapiens

Also known as MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3

Gene ID: 8649 | Gene type: protein coding

About LAMTOR3

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,878,336-99,894,546 (from NCBI)

This gene has 3 transcripts (splice variants) and 220 orthologues. Ubiquitous expression in thyroid (RPKM 13.3), brain (RPKM 11.2) and 25 other tissues.

Summary

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

LAMTOR3 Products(2)

mRNA	Protein	Name
NM_001243736.1	NP_001230665.1	ragulator complex protein LAMTOR3 isoform 2
NM_021970.4	NP_068805.1	ragulator complex protein LAMTOR3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	22980980	GOA
contributes to molecular adaptor activity	IDA IDA: Inferred from direct assay	22980980	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20381137	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	22980980	GOA
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	28935770	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	20381137	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FNIP-folliculin RagC/D GAP	IDA IDA: Inferred from direct assay	36103527	GOA
part of Ragulator complex	IDA IDA: Inferred from direct assay	20381137	GOA
part of Ragulator complex	IPI IPI: Inferred from physical interaction	28935770	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	29158492	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAMTOR3 Protein Structure

MAPKK1_Int

0
100
124 a.a.

Protein Preferred Names

Protein Names

ragulator complex protein LAMTOR3

MAPK scaffold protein 1

LAMTOR3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LAMTOR3	Q9UHA4	TFE3	Homo sapiens	P19532	Y2H Array	32296183
Intra	LAMTOR3	Q9UHA4	TFE3	Homo sapiens	P19532	Y2H Prey Pooling	32296183
Intra	LAMTOR3	Q9UHA4	TGM7	Homo sapiens	Q96PF1	Y2H Array	32296183
Intra	LAMTOR3	Q9UHA4	TGM7	Homo sapiens	Q96PF1	Y2H Prey Pooling	32296183
Intra	LAMTOR3	Q9UHA4	LAMTOR2	Homo sapiens	Q9Y2Q5	Anti Tag CoIP	25561175
Intra	LAMTOR3	Q9UHA4	LAMTOR2	Homo sapiens	Q9Y2Q5	Y2H	21516116
Intra	LAMTOR3	Q9UHA4	LAMTOR2	Homo sapiens	Q9Y2Q5	Y2H Prey Pooling	25416956
Intra	LAMTOR3	Q9UHA4	LAMTOR2	Homo sapiens	Q9Y2Q5	Y2H Prey Pooling	32296183
Intra	LAMTOR3	Q9UHA4	LAMTOR2	Homo sapiens	Q9Y2Q5	Y2H Array	25416956
Intra	LAMTOR3	Q9UHA4	LAMTOR1	Homo sapiens	Q6IAA8	BRET	37398436
Intra	LAMTOR3	Q9UHA4	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	33961781
Intra	LAMTOR3	Q9UHA4	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	25561175
Intra	LAMTOR3	Q9UHA4	ZSCAN4	Homo sapiens	Q8NAM6	Y2H Array	32296183
Intra	LAMTOR3	Q9UHA4	ZSCAN4	Homo sapiens	Q8NAM6	Y2H Prey Pooling	32296183
Intra	LAMTOR3	Q9UHA4	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	25416956
Intra	LAMTOR3	Q9UHA4	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	33961781
Intra	LAMTOR3	Q9UHA4	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25561175

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LAMTOR3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70931	MAPKSP1 Protein, Human (His)	Q9UHA4 (M1-S124)	≥95%

Related Diseases

Diseases

Alias

3-Methylcrotonyl-Coa Carboxylase 2 Deficiency

MCC2D	Mcc2 Deficiency
3-Methylcrotonyl Coa Carboxylase 2 Deficiency	3-Methylcrotonylglycinuria Ii
Methylcrotonylglycinuria, Type Ii	3-Methylcrotonoyl-Coa Carboxylase 2 Deficiency
3-Methylcrotonylglycinuria Type Ii	Mcgii
Methylcrotonylglycinuria Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07515	LAMTOR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LAMTOR3	MGD	MGI:1929467
Canis familiaris	LAMTOR3	VGNC	VGNC:42578
Rattus norvegicus	LAMTOR3	RGD	RGD:1307133
Bos taurus	LAMTOR3	VGNC	VGNC:30781
Macaca mulatta	LAMTOR3	VGNC	VGNC:100240
Others	LAMTOR3	NCBI

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