2. Gene
  3. RNMT - RNA guanine-7 methyltransferase Gene

RNMT - RNA guanine-7 methyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1; N7-MTase

Gene ID: 8731 | Gene type: protein coding

About RNMT

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,726,673-13,764,556 (from NCBI)

This gene has 10 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues.

Summary

Enables RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

RNMT Products(5)

mRNA Protein Name
NM_001308263.2 NP_001295192.1 mRNA cap guanine-N7 methyltransferase isoform 1
NM_001378132.1 NP_001365061.1 mRNA cap guanine-N7 methyltransferase isoform 3
NM_001378134.1 NP_001365063.1 mRNA cap guanine-N7 methyltransferase isoform 1
NM_001378135.1 NP_001365064.1 mRNA cap guanine-N7 methyltransferase isoform 2
NM_003799.3 NP_003790.1 mRNA cap guanine-N7 methyltransferase isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IMP
IMP: Inferred from mutant phenotype
9790902 GOA
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IDA
IDA: Inferred from direct assay
22099306 GOA
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
9790902 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22099306 GOA
Biological Process GO Annotation Evidence Reference Source
involved in 7-methylguanosine mRNA capping IDA
IDA: Inferred from direct assay
27422871 GOA
involved in 7-methylguanosine mRNA capping IMP
IMP: Inferred from mutant phenotype
9790902 GOA
Cellular Component GO Annotation Evidence Reference Source
part of mRNA cap methyltransferase RNMT:RAMAC complex IDA
IDA: Inferred from direct assay
22099306 GOA
part of mRNA capping enzyme complex IDA
IDA: Inferred from direct assay
27422871 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9790902 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNMT Protein Structure

Pox_MCEL

Pox_MCEL: mRNA capping enzyme (137 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

mRNA cap guanine-N7 methyltransferase

RNA (guanine-7-) methyltransferase

RNMT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20
Validated Y2H
32296183
Intra
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20
Y2H Array
32296183
Intra
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20
Y2H Prey Pooling
32296183
Intra
RNMT O43148 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra
RNMT O43148 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
RNMT O43148 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra
RNMT O43148 KPNA2 Homo sapiens P52292
Y2H Array
32296183
Intra
RNMT O43148 KPNA2 Homo sapiens P52292
Y2H Prey Pooling
32296183
Intra
RNMT O43148 KPNA2 Homo sapiens P52292
Validated Y2H
32296183
Intra
RNMT O43148 KPNA6 Homo sapiens O60684
Anti Tag CoIP
33961781
Intra
RNMT O43148 KPNA6 Homo sapiens O60684
Validated Y2H
32296183
Intra
RNMT O43148 KPNA6 Homo sapiens O60684
Y2H Prey Pooling
32296183
Intra
RNMT O43148 KPNA6 Homo sapiens O60684
Y2H Array
32296183
Intra
RNMT O43148 RAMAC Homo sapiens Q9BTL3
Crosslink
30021884
Intra
RNMT O43148 RAMAC Homo sapiens Q9BTL3
Y2H Array
32296183
Intra
RNMT O43148 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
Intra
RNMT O43148 RAMAC Homo sapiens Q9BTL3
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microphthalmia, Isolated 6

Isolated Microphthalmia 6

MCOP6

Microphthalmia, Posterior Nonsyndromic

Posterior Nonsyndromic Microphthalmia

Microphthalmia, Isolated, 6

Autosomal Recessive Posterior Microphthalmos

Posterior Non-Syndromic Microphthalmia

Microphthalmia, Isolated, Type 6
Cardiomyopathy, Familial Restrictive, 1

RCM1

Restrictive Cardiomyopathy 1

Rcm

Familial Restrictive Cardiomyopathy 1

Cardiomyopathy, Familial Restrictive 1

Cardiomyopathy, Restrictive, Familial, Type 1

Rcm-1
Dubowitz Syndrome

Dubowitz'S Syndrome

Dwarfism-Eczema-Peculiar Facies Syndrome

Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci
Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency

Deficiency Of Methionine Adenosyltransferase

Glycine N-Methyltransferase Deficiency

Met

S-Adenosylhomocysteine Hydrolase Deficiency

Gnmt Deficiency

Mat Deficiency

Methionine Adenosyltransferase Deficiency

Methioninemia

Deficiency Of Acetyl-Coa Acetyltransferase
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128464 LL320 / Unkown
HY-RS12102 RNMT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RNMT MGD MGI:1915147
Bos taurus RNMT VGNC VGNC:34077
Felis catus RNMT VGNC VGNC:64710
Rattus norvegicus RNMT RGD RGD:1309242
Macaca mulatta RNMT VGNC VGNC:76710