TNFSF14 - TNF superfamily member 14 Gene

Homo sapiens

Also known as LTg; CD258; HVEML; LIGHT

Gene ID: 8740 | Gene type: protein coding

About TNFSF14

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,661,253-6,670,588 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 8 paralogues. Broad expression in liver (RPKM 1.5), appendix (RPKM 0.9) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to Infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger Apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated Apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TNFSF14 Products(3)

mRNA	Protein	Name
NM_001376887.1	NP_001363816.1	tumor necrosis factor ligand superfamily member 14 isoform 1
NM_003807.5	NP_003798.2	tumor necrosis factor ligand superfamily member 14 isoform 1
NM_172014.3	NP_742011.2	tumor necrosis factor ligand superfamily member 14 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12393901	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25087510	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9462508	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12393901	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell costimulation	IDA IDA: Inferred from direct assay	10754304	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	12393901	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFSF14 Protein Structure

TNF

0
100
200
240 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor ligand superfamily member 14

herpesvirus entry mediator ligand

TNFSF14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNFSF14	O43557	ADAM33	Homo sapiens	Q08AM2	Validated Y2H	32296183
Intra	TNFSF14	O43557	ZDHHC24	Homo sapiens	Q6UX98	Validated Y2H	32296183
Intra	TNFSF14	O43557	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	TNFSF14	O43557	TNFRSF14	Homo sapiens	Q92956	FACS	10318773
Intra	TNFSF14	O43557	TNFRSF14	Homo sapiens	Q92956	Yeast Display	26977880
Intra	TNFSF14	O43557	TNFRSF14	Homo sapiens	Q92956	ELISA	26977880
Intra	TNFSF14	O43557	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Cross	TNFSF14	O43557	Tnfrsf14	Mus musculus	Q71F55	Yeast Display	26977880
Cross	TNFSF14	O43557	Tnfrsf14	Mus musculus	Q71F55	ELISA	26977880
Intra	TNFSF14	O43557	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	TNFSF14	O43557	CLDN11	Homo sapiens	O75508	Validated Y2H	32296183
Intra	TNFSF14	O43557	LHFPL3	Homo sapiens	Q86UP9	Validated Y2H	32296183
Intra	TNFSF14	O43557	SYS1	Homo sapiens	Q8N2H4	Validated Y2H	32296183
Intra	TNFSF14	O43557	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	32296183
Intra	TNFSF14	O43557	LTBR	Homo sapiens	P36941	Yeast Display	26977880
Intra	TNFSF14	O43557	LTBR	Homo sapiens	P36941	ELISA	26977880
Intra	TNFSF14	O43557	PTTG1IP	Homo sapiens	P53801	Validated Y2H	32296183
Intra	TNFSF14	O43557	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	TNFSF14	O43557	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	TNFSF14	O43557	BMP10	Homo sapiens	O95393	Validated Y2H	32296183
Intra	TNFSF14	O43557	MAL	Homo sapiens	P21145	Validated Y2H	32296183
Intra	TNFSF14	O43557	TNFRSF6B	Homo sapiens	O95407	Anti Tag CoIP	10318773
Intra	TNFSF14	O43557	TNFRSF6B	Homo sapiens	O95407	FACS	10318773
Cross	TNFSF14	O43557	Ltbr	Mus musculus	P50284	Yeast Display	26977880
Cross	TNFSF14	O43557	Ltbr	Mus musculus	P50284	ELISA	26977880
Intra	TNFSF14	O43557	TMEM11	Homo sapiens	P17152	Anti Tag CoIP	33961781
Intra	TNFSF14	O43557	TMEM11	Homo sapiens	P17152	Validated Y2H	32296183
Intra	TNFSF14	O43557	SEC23A	Homo sapiens	Q15436	Validated Y2H	32296183
Intra	TNFSF14	O43557	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFSF14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72033	LIGHT/TNFSF14 Protein, Human (HEK293, hFC-Myc)	O43557 (D74-V240)	≥95%
HY-P72522	LIGHT/TNFSF14 Protein, Human (HEK293, His)	AAC39563.1 (L83-V240)	≥95%
HY-P73281	LIGHT/TNFSF14 Protein, Human (HEK293, Fc)	O43557 (D74-V240)	≥95%
HY-P78477	LIGHT/TNFSF14 Trimer Protein, Human (HEK293, His-Flag)	O43557 (S89-V240)	≥95%
HY-P700136AF	Animal-Free LIGHT/TNFSF14 Protein, Human (His)	O43557 (R64-V240)	≥95%

Related Diseases

Diseases

Alias

St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99810	Quisovalimab		96.18%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14825	TNFSF14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TNFSF14	VGNC	VGNC:36173
Macaca mulatta	TNFSF14	VGNC	VGNC:78595
Canis familiaris	TNFSF14	VGNC	VGNC:47670
Felis catus	TNFSF14	VGNC	VGNC:66414
Mus musculus	TNFSF14	MGD	MGI:1355317
Rattus norvegicus	TNFSF14	RGD	RGD:1588572
Others	TNFSF14	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.