2. Gene
  3. SEC23A - SEC23 homolog A, COPII coat complex component Gene

SEC23A - SEC23 homolog A, COPII coat complex component Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CLSD; hSec23A

Gene ID: 10484 | Gene type: protein coding

About SEC23A

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:39,031,919-39,103,235 (from NCBI)

This gene has 15 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 27.6), small intestine (RPKM 25.4) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]

SEC23A Products(1)

mRNA Protein Name
NM_006364.4 NP_006355.2 protein transport protein Sec23A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10075675 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
18843296 GOA
Biological Process GO Annotation Evidence Reference Source
involved in COPII-coated vesicle cargo loading IDA
IDA: Inferred from direct assay
17499046 GOA
involved in COPII-coated vesicle cargo loading IGI
IGI: Inferred from genetic interaction
8898360 GOA
Cellular Component GO Annotation Evidence Reference Source
part of COPII vesicle coat IDA
IDA: Inferred from direct assay
17499046 GOA
located in ER to Golgi transport vesicle membrane IGI
IGI: Inferred from genetic interaction
8898360 GOA
located in cytosol IDA
IDA: Inferred from direct assay
8898360 GOA
located in endoplasmic reticulum exit site IDA
IDA: Inferred from direct assay
8898360 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC23A Protein Structure

zf-Sec23_Sec24

zf-Sec23_Sec24: Sec23/Sec24 zinc finger (57 - 98)

Sec23_trunk

Sec23_trunk: Sec23/Sec24 trunk domain (126 - 390)

Sec23_BS

Sec23_BS: Sec23/Sec24 beta-sandwich domain (401 - 504)

Sec23_helical

Sec23_helical: Sec23/Sec24 helical domain (519 - 619)

Gelsolin

Gelsolin: Gelsolin repeat (631 - 718)

  • 0
  • 200
  • 400
  • 600
  • 765 a.a.
Protein Preferred Names Protein Names

protein transport protein Sec23A

SEC23-related protein A

SEC23A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SEC23A Q15436 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra
SEC23A Q15436 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
SEC23A Q15436 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
SEC23A Q15436 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra
SEC23A Q15436 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 CLEC17A Homo sapiens Q6ZS10
Validated Y2H
32296183
Intra
SEC23A Q15436 MINAR1 Homo sapiens Q9UPX6
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 MINAR1 Homo sapiens Q9UPX6
Validated Y2H
32296183
Intra
SEC23A Q15436 MINAR1 Homo sapiens Q9UPX6
Y2H Array
32296183
Intra
SEC23A Q15436 SF1 Homo sapiens Q15637-4
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 SF1 Homo sapiens Q15637-4
Validated Y2H
32296183
Intra
SEC23A Q15436 SF1 Homo sapiens Q15637-4
Y2H Array
32296183
Intra
SEC23A Q15436 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SEC23A Q15436 SEC23IP Homo sapiens Q9Y6Y8
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 SEC23IP Homo sapiens Q9Y6Y8
Y2H Array
32296183
Intra
SEC23A Q15436 SEC23IP Homo sapiens Q9Y6Y8
Validated Y2H
32296183
Intra
SEC23A Q15436 SEC23IP Homo sapiens Q9Y6Y8
Anti Tag CoIP
33961781
Intra
SEC23A Q15436 SUCLA2 Homo sapiens Q9P2R7
Validated Y2H
32296183
Intra
SEC23A Q15436 MIA3 Homo sapiens Q5JRA6
Validated Y2H
32296183
Intra
SEC23A Q15436 MIA3 Homo sapiens Q5JRA6
Y2H Array
32296183
Intra
SEC23A Q15436 MIA3 Homo sapiens Q5JRA6
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
Intra
SEC23A Q15436 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra
SEC23A Q15436 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 DNM2 Homo sapiens P50570
Y2H Array
32296183
Intra
SEC23A Q15436 DNM2 Homo sapiens P50570
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
SEC23A Q15436 ERLIN1 Homo sapiens O75477
Y2H Array
32296183
Intra
SEC23A Q15436 ERLIN1 Homo sapiens O75477
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra
SEC23A Q15436 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
SEC23A Q15436 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
SEC23A Q15436 FASLG Homo sapiens P48023
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 FASLG Homo sapiens P48023
Y2H Array
32296183
Intra
SEC23A Q15436 TNFSF14 Homo sapiens O43557
Y2H Array
32296183
Intra
SEC23A Q15436 TNFSF14 Homo sapiens O43557
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 WBP11 Homo sapiens Q9Y2W2
Validated Y2H
32296183
Intra
SEC23A Q15436 WBP11 Homo sapiens Q9Y2W2
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 WBP11 Homo sapiens Q9Y2W2
Y2H Array
32296183
Intra
SEC23A Q15436 CDK16 Homo sapiens Q00536
Anti Bait CoIP
16091426
Intra
SEC23A Q15436 CDK16 Homo sapiens Q00536
Y2H
16091426
Intra
SEC23A Q15436 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
SEC23A Q15436 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
SEC23A Q15436 SEC23B Homo sapiens Q15437
Validated Y2H
32296183
Intra
SEC23A Q15436 SEC23B Homo sapiens Q15437
Anti Tag CoIP
33961781
Intra
SEC23A Q15436 SEC23B Homo sapiens Q15437
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 SEC23B Homo sapiens Q15437
Y2H Array
32296183
Intra
SEC23A Q15436 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
SEC23A Q15436 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
SEC23A Q15436 SEC24D Homo sapiens O94855
Anti Tag CoIP
33961781
Intra
SEC23A Q15436 SEC24D Homo sapiens O94855
Anti Tag CoIP
35271311
Intra
SEC23A Q15436 BNIP3 Homo sapiens Q12983
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 BNIP3 Homo sapiens Q12983
Y2H Array
32296183
Intra
SEC23A Q15436 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
SEC23A Q15436 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
SEC23A Q15436 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
SEC23A Q15436 SEC24B Homo sapiens O95487
Anti Tag CoIP
35271311
Intra
SEC23A Q15436 SEC24B Homo sapiens O95487
Anti Tag CoIP
33961781
Intra
SEC23A Q15436 SEC24C Homo sapiens P53992
Cosedimentation
18692470
Intra
SEC23A Q15436 SEC24C Homo sapiens P53992
Anti Tag CoIP
33961781
Intra
SEC23A Q15436 SEC24C Homo sapiens P53992
EM
18692470
Intra
SEC23A Q15436 SEC24C Homo sapiens P53992
Y2H
10075675
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda

X-Linked Spondyloepiphyseal Dysplasia Tarda

SEDT

Sed Tarda, X-Linked

Spondyloepiphyseal Dysplasia, Late

Spondyloepiphyseal Dysplasia Tarda X-Linked

Sed

X Linked Spondyloepiphyseal Dysplasia Tarda

X-Linked Spondyloepiphyseal Dysplasia

Late Onset Spondyloepiphyseal Dysplasia

Sed Tarda

X-Linked Sed

X-Linked Sedt

Dysplasia, Spondyloepiphyseal, Tarda

Spondyloepiphyseal Dysplasia
Anemia, Congenital Dyserythropoietic, Type Ii

Congenital Dyserythropoietic Anemia Type Ii

CDAN2

Cda Ii

Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test

Cda Type Ii

Congenital Dyserythropoietic Anemia Type 2

Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test

Sec23b-Cdg

Congenital Dyserythropoietic Anemia, Type Ii

Dyserythropoietic Anemia, Hempas Type

Hempas

Cda Type 2

Dyserythropoietic Anemia, Congenital, Type Ii

Cda, Type Ii

Congenital Dyserythropoietic Anaemia Type 2

Congenital Dyserythropoietic Anaemia Type Ii

Anemia, Dyserythropoietic, Congenital Type 2

Hempas Anemia

Dyserythropoietic Anemia, Congenital Type 2

Anemia, Congenital Dyserythropoietic, 2

Dyserythropoietic Anemia Hempas Type

Anemia, Dyserythropoietic Congenital, Type Ii

Anemia, Dyserythropoietic, Congenital, Type Ii
Camptodactyly-Tall Stature-Scoliosis-Hearing Loss Syndrome

Catshl Syndrome

Camptodactyly-Tall Stature-Scoliosis-Deafness Syndrome
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome

Smed-Sl

Smed-Sl/Ac

Smed Short Limb-Abnormal Calcification Type

Smed Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia Short Limb-Hand Type

Smed, Type Ii

Smed Type 2

Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type

Smed, Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type

Smed, Short Limb-Abnormal Calcification Type

Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification

Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type

SEMD-SL

Smed Type Ii

Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
Cole-Carpenter Syndrome

Cole Carpenter Syndrome

Bone Fragility Craniosynostosis Proptosis Hydrocephalus

Bone Fragility With Craniosynostosis, Ocular Proptosis, Hydrocephalus, And Distinctive Facial Features

Bone Fragility-Craniosynostosis-Proptosis-Hydrocephalus Syndrome
Spondyloepiphyseal Dysplasia Congenita

SEDC

Sed Congenita

Spondyloepiphyseal Dysplasia, Congenital Type

Late Spondyloepiphyseal Dysplasia

Sed, Congenital Type

Congenital Spondyloepiphyseal Dysplasia

Spranger-Wiedemann Disease

Spondyloepiphyseal Dysplasia Congenital Type

Dysplasia, Spondyloepiphyseal, Congenita

Spondyloepiphyseal Dysplasia, Congenita

Spondyloepiphyseal Dysplasia Tarda, X-Linked
Geroderma Osteodysplasticum

Gerodermia Osteodysplastica

Geroderma Osteodysplastica

GO

Walt Disney Dwarfism

Type Of Gerodermia Osteodysplastica
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12612 SEC23A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SEC23A RGD RGD:1309103
Bos taurus SEC23A VGNC VGNC:34410
Canis familiaris SEC23A VGNC VGNC:45969
Mus musculus SEC23A MGD MGI:1349635
Felis catus SEC23A VGNC VGNC:64966
Macaca mulatta SEC23A VGNC VGNC:77150