2. Gene
  3. SYS1 - SYS1 golgi trafficking protein Gene

SYS1 - SYS1 golgi trafficking protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C20orf169; dJ453C12.4; dJ453C12.4.1

Gene ID: 90196 | Gene type: protein coding

About SYS1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,361,949-45,376,798 (from NCBI)

This gene has 8 transcripts (splice variants), 192 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 8.9), ovary (RPKM 6.7) and 25 other tissues.

Summary

SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al., 2004 [PubMed 15077113]).[supplied by OMIM, Aug 2009]

SYS1 Products(3)

mRNA Protein Name
NM_001099791.3 NP_001093261.1 protein SYS1 homolog isoform b
NM_001197129.2 NP_001184058.1 protein SYS1 homolog isoform a
NM_033542.4 NP_291020.1 protein SYS1 homolog isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYS1 Protein Structure

SYS1

SYS1: Integral membrane protein S linking to the trans Golgi network (5 - 148)

  • 0
  • 100
  • 156 a.a.
Protein Preferred Names Protein Names

protein SYS1 homolog

SYS1 Golgi-localized integral membrane protein homolog

SYS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SYS1 Q8N2H4 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
Intra
SYS1 Q8N2H4 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
Intra
SYS1 Q8N2H4 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
SYS1 Q8N2H4 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 ELOVL5 Homo sapiens Q9NYP7
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 ELOVL5 Homo sapiens Q9NYP7
Y2H Array
32296183
Intra
SYS1 Q8N2H4 ELOVL5 Homo sapiens Q9NYP7
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 KIR3DL3 Homo sapiens Q8N743
Y2H Array
32296183
Intra
SYS1 Q8N2H4 KIR3DL3 Homo sapiens Q8N743
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 KIR3DL3 Homo sapiens Q8N743
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
SYS1 Q8N2H4 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 IL3RA Homo sapiens P26951
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 IL3RA Homo sapiens P26951
Y2H Array
32296183
Intra
SYS1 Q8N2H4 BTNL9 Homo sapiens Q6UXG8-3
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 BTNL9 Homo sapiens Q6UXG8-3
Y2H Array
32296183
Intra
SYS1 Q8N2H4 MCFD2 Homo sapiens Q8NI22
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 MCFD2 Homo sapiens Q8NI22
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 MCFD2 Homo sapiens Q8NI22
Y2H Array
32296183
Intra
SYS1 Q8N2H4 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
SYS1 Q8N2H4 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
SYS1 Q8N2H4 TNFSF14 Homo sapiens O43557
Y2H Array
32296183
Intra
SYS1 Q8N2H4 TNFSF14 Homo sapiens O43557
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
SYS1 Q8N2H4 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
SYS1 Q8N2H4 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 MRPS18B Homo sapiens Q9Y676
Y2H Array
32296183
Intra
SYS1 Q8N2H4 MRPS18B Homo sapiens Q9Y676
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 MRPS18B Homo sapiens Q9Y676
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
SYS1 Q8N2H4 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
SYS1 Q8N2H4 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alkuraya-Kucinskas Syndrome

ALKKUCS

Kiaa1109-Related Early Lethal Congenital Brain Malformations-Arthrogryposis Syndrome

Arthrogryposis
Limited Scleroderma

Limited Cutaneous Systemic Sclerosis

Limited Systemic Sclerosis

Systemic Sclerosis Sine Scleroderma

Crest Syndrome

Limited Cutaneous Systemic Scleroderma

Scleroderma, Limited

Systemic Sclerosis, Limited

Progressive Systemic Sclerosis Sine Scleroderma

Scleroderma, Sine

Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14105 SYS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SYS1 VGNC VGNC:97315
Canis familiaris SYS1 VGNC VGNC:54736
Mus musculus SYS1 MGD MGI:1913710
Rattus norvegicus SYS1 RGD RGD:1583224