SUCLA2 - succinate-CoA ligase ADP-forming subunit beta Gene

Homo sapiens

Also known as A-SCS; A-BETA; MTDPS5; LINC00444; SCS-betaA

Gene ID: 8803 | Gene type: protein coding

About SUCLA2

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:47,942,656-48,001,273 (from NCBI)

This gene has 20 transcripts (splice variants), 230 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 24.1), fat (RPKM 23.0) and 25 other tissues.

Summary

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix Enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

SUCLA2 Products(1)

mRNA	Protein	Name
NM_003850.3	NP_003841.1	succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10727444	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	10727444	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUCLA2 Protein Structure

ATP-grasp_2

Ligase_CoA

0
100
200
300
400
463 a.a.

Protein Preferred Names

Protein Names

succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

ATP-specific succinyl-CoA synthetase subunit beta

SUCLA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUCLA2	Q9P2R7	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	SUCLA2	Q9P2R7	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	SUCLA2	Q9P2R7	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	SUCLA2	Q9P2R7	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	26871637
Intra	SUCLA2	Q9P2R7	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	26871637
Intra	SUCLA2	Q9P2R7	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	26871637
Intra	SUCLA2	Q9P2R7	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	SUCLA2	Q9P2R7	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	26871637
Intra	SUCLA2	Q9P2R7	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	26871637
Intra	SUCLA2	Q9P2R7	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	SUCLA2	Q9P2R7	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	26871637
Intra	SUCLA2	Q9P2R7	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	SUCLA2	Q9P2R7	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	SUCLA2	Q9P2R7	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	SUCLA2	Q9P2R7	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	SUCLA2	Q9P2R7	ARL6IP1	Homo sapiens	Q15041	Y2H Array	26871637
Intra	SUCLA2	Q9P2R7	ARL6IP1	Homo sapiens	Q15041	Y2H Array	32296183
Intra	SUCLA2	Q9P2R7	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	26871637
Intra	SUCLA2	Q9P2R7	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	32296183
Intra	SUCLA2	Q9P2R7	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	26871637
Intra	SUCLA2	Q9P2R7	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	SUCLA2	Q9P2R7	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	SUCLA2	Q9P2R7	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	SUCLA2	Q9P2R7	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	SUCLA2	Q9P2R7	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	SUCLA2	Q9P2R7	SEC23A	Homo sapiens	Q15436	Y2H Prey Pooling	32296183
Intra	SUCLA2	Q9P2R7	SEC23A	Homo sapiens	Q15436	Y2H Array	32296183
Intra	SUCLA2	Q9P2R7	MAL2	Homo sapiens	Q969L2	Y2H Prey Pooling	32296183
Intra	SUCLA2	Q9P2R7	MAL2	Homo sapiens	Q969L2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mitochondrial Dna Depletion Syndrome 5

Succinate-Coa Ligase Deficiency	Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Methylmalonic Aciduria
MTDPS5	Booth-Haworth-Dilling Syndrome
Mtdna Depletion Syndrome, Encephalomyopathic Form With Methylmalonic Aciduria	Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form, With Or Without Methylmalonic Aciduria, Autosomal Recessive, Sucla2-Related
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Methylmalonic	Mitochondrial Dna Depletion Syndrome-5
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Methylmalonic Aciduria, Autosomal Recessive	Mitochondrial Encephalomyopathy Aminoacidopathy
Sucla2-Related Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Methylmalonic Aciduria	Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form, With Mild Methylmalonic Aciduria
Mitochondrial Dna Depletion, Encephalomyopathic Form, With Methylmalonic Aciduria	Succinate-Coenzyme A Ligase Deficiency
Mitochondrial Encephalomyopathy-Aminoacidopathy Syndrome	Encephalomyopathic Mitochondrial Dna Depletion Syndrome With Or Without Methylmalonic Aciduria
Mitochondrial Dna Depletion Syndrome 5 Encephalomyopathic With Or Without Methylmalonic Aciduria	Mitochondrial Dna Depletion Syndrome Encephalomyopathic Form With Or Without Methylmalonic Aciduria Autosomal Recessive Sucla2-Related
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form, With Methylmalonic Aciduria, Autosomal Recessive	Mitochondrial Dna Depletion Syndrome, Type 5

Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome

Gaba Aminotransferase Deficiency

Gamma-Aminobutyric Acid Transaminase Deficiency	Gamma Aminobutyric Acid Transaminase Deficiency
Gaba Transaminase Deficiency	Gamma-Amino Butyric Acid Transaminase Deficiency
4 Alpha Aminobutyrate Transaminase Deficiency	Abat
Gabat	Gamma Aminobutyrate Transaminase Deficiency

Mitochondrial Dna Depletion Syndrome 6

Navajo Neurohepatopathy	Navajo Neuropathy
MTDPS6	Nnh
Nn	Mpv17-Related Hepatocerebral Mitochondrial Dna Depletion Syndrome
Navajo Familial Neurogenic Arthropathy	Mpv17-Associated Hepatocerebral Mds
Mitochondrial Dna Depletion 6 Hepatocerebral Type	Mitochondrial Dna Depletion Syndrome , Type 6

Combined Oxidative Phosphorylation Deficiency 13

COXPD13	Combined Oxidative Phosphorylation Defect Type 13
Combined Oxidative Phosphorylation Deficiency, Type 13

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 4

PEOA4	Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 4
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 4	Chronic Progressive External Ophthalmoplegia
Progressive External Ophthalmoplegia, Autosomal Dominant 4	Autosomal Dominant Progressive External Ophthalmoplegia 4
Cpeo	Graefe Disease
Mitochondrial Ocular Myopathy	Ocular Myopathy Of Von Graefe-Fuchs
Progressive External Ophthalmoplegia Autosomal Dominant 4	Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 4
Kearns-Sayre Syndrome

Mitochondrial Dna Depletion Syndrome 9

MTDPS9	Fatal Infantile Lactic Acidosis
Lactic Acidosis, Fatal Infantile, Formerly	Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Mitochondrial Dna Depletion Syndrome 9 Encephalomyopathic Type With Methylmalonic Aciduria	Mitochondrial Dna Depletion Syndrome, Type 9
Lactic Acidosis, Fatal Infantile

Infantile Cerebellar-Retinal Degeneration

ICRD	Infantile Cerebellar Retinal Degeneration
Degeneration, Cerebellar-Retinal, Infantile

Fumarase Deficiency

Fumaric Aciduria	FMRD
Fumarate Hydratase Deficiency	Deficiency, Fumarase

Combined Malonic And Methylmalonic Aciduria

CMAMMA	Combined Malonic And Methylmalonic Acidemia
Aciduria, Combined Malonic And Methylmalonic

Methylmalonic Aciduria, Cbla Type

Methylmalonic Acidemia Cbla Type	Methylmalonic Aciduria Cbla Type
Methylmalonic Acidemia, Cbla Type	Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cbla Type
Methylmalonic Aciduria, Vitamin B12-Responsive, Cbla Type	Methylmalonic Aciduria, Vitamin B12-Responsive Due To A Defect In Synthesis Of Adenosylcobalamin Cb1a Type
Vitamin B12-Responsive Methylmalonic Acidemia Type Cbla	Vitamin B12-Responsive Methylmalonic Aciduria Type Cbla
Methylmalonic Aciduria Type Cbla	MMAA
Methylmalonic Aciduria Type A	Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl A
Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl A	Aciduria, Methylmalonic, Cbla Type
Methylmalonic Aciduria Cbla Type

Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency

Methylmalonyl-Coenzyme A Mutase Deficiency	Methylmalonic Aciduria, Mut Type
Methylmalonic Aciduria, Mut(0) Type	Methylmalonic Acidemia Due To Methylmalonyl-Coa Mutase Deficiency
Vitamin B12-Unresponsive Methylmalonic Aciduria	Vitamin B12-Unresponsive Methylmalonic Acidemia
Methylmalonic Aciduria, Mut Type	Mma Due To Mcm Deficiency
Methylmalonic Aciduria Mut Type	Mcm Deficiency
Methylmalonyl-Coa Mutase Deficiency	Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut0
Complete Deficiency Of Methylmalonyl-Coa Mutase	Vitamin B12-Unresponsive Methylmalonic Aciduria Type Mut0
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-	Partial Deficiency Of Methylmalonyl-Coa Mutase
Vitamin B12-Unresponsive Methylmalonic Aciduria Type Mut-	MMAM
Methylmalonicaciduria Due To Methylmalonyl-Coa Mutase Deficiency	Methylmalonic Aciduria Type Mut
Methylmalonicaciduria Vitamin B12 Unresponsive	Aciduria, Methylmalonic, Due To Methylmalonyl-Coa Mutase Deficiency

Mitochondrial Metabolism Disease

Abnormality Of Mitochondrial Metabolism

Mitochondrial Diseases

Mitochondrial Dna Depletion Syndrome 7

Ohaha Syndrome	Infantile Onset Spinocerebellar Ataxia
Iosca	Infantile-Onset Spinocerebellar Ataxia
Spinocerebellar Ataxia 8	MTDPS7
Ophthalmoplegia, Hypotonia, Ataxia, Hypacusis, And Athetosis	Ophthalmoplegia-Hypotonia-Ataxia-Hypoacusis-Athetosis Syndrome
Sca8	Spinocerebellar Ataxia Infantile With Sensory Neuropathy
Spinocerebellar Ataxia, Infantile-Onset	Ophthalmoplegia, Hypotonia, Ataxia, Hypoacusis, And Athetosis
Spinocerebellar Ataxia, Infantile, With Sensory Neuropathy	Spinocerebellar Ataxia 8, Formerly
Sca8, Formerly	Iosca, Mitochondrial Dna Depletion Syndrome 7
Ophthalmoplegia - Hypotonia - Ataxia - Hypoacusis - Athetosis	Mitochondrial Dna Depletion Syndrome, Hepatocerebrorenal Form
Mtdna Depletion Syndrome, Hepatocerebrorenal Form	Mitochondrial Dna Depletion Syndrome 7 Hepatocerebral Type
Ophthalmoplegia Hypotonia Ataxia Hypoacusis And Athetosis	Pure Spinocerebellar Ataxia Japanese Type
Sca4 Pure Japanese Type	Spinocerebellar Ataxia Infantile-Onset
Mitochondrial Dna Depletion Syndrome , Type 7

3-Methylglutaconic Aciduria With Deafness, Encephalopathy, And Leigh-Like Syndrome

Megdel Syndrome	MEGDEL
Mgca6	3-Methylglutaconic Aciduria With Dystonia-Deafness, Hepatopathy, Encephalopathy, And Leigh-Like Syndrome
Megdhel	3-Methylglutaconic Aciduria, Type Vi
Serac1 Defect	3-Methylglutaconic Aciduria Type 6
3-Mgca Type Iv	3-Mgca-4
3-Methylglutaconic Aciduria Type Vi	3-Methylglutaconic Aciduria Type Iv With Sensorineural Deafness, Encephalopathy, And Leigh-Like Syndrome
Megdhel Syndrome	3-Methylglutaconic Aciduria With Deafness-Encephalopathy-Leigh-Like Syndrome
3-Methylglutaconic Aciduria With Hearing Loss-Encephalopathy-Leigh-Like Syndrome	3-Methylglutaconic Aciduria With Deafness, Encephalopathy, Leigh-Like Syndrome
3-Methylglutaconic Aciduria Type Iv With Sensorineural Deafness, Encephalopathy And Leigh-Like Syndrome

3-Methylglutaconic Aciduria, Type Iv

3-Methylglutaconic Aciduria Type 4	Mga4
MGCA4	3-Methylglutaconic Aciduria Type Iv
Mga, Type Iv	Mga Type Iv
Not Otherwise Specified 3-Mga-Uria Type	3 Alpha Methylglutaconic Aciduria Type Iv
3 Methylglutaconic Aciduria Type Iv

Kearns-Sayre Syndrome

Ophthalmoplegia	Mitochondrial Cytopathy
KSS	Ophthalmoplegia, Pigmentary Degeneration Of Retina, And Cardiomyopathy
Oculocraniosomatic Syndrome	Chronic Progressive External Ophthalmoplegia With Myopathy
Cpeo With Myopathy	Total Ophthalmoplegia
Ophthalmoplegia-Plus Syndrome	Ophthalmoplegia, Progressive External, With Ragged-Red Fibers
Cpeo With Ragged-Red Fibers	Oculomotor Paralysis
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication O	Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication Of Mitochondrial Dna
Proximal Tubulopathy, Diabetes Mellitus And Cerebellar Ataxia	Cpeo With Ragged Red Fibers
Ophthalmoplegia Plus Syndrome	Ophthalmoplegia, Progressive External, With Ragged Red Fibers
Kearns-Sayre Mitochondrial Cytopathy	Mitochondrial Myopathies

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Mitochondrial Dna Depletion Syndrome 4a

Alpers Syndrome	Alpers-Huttenlocher Syndrome
Alpers Progressive Infantile Poliodystrophy	Alpers Diffuse Degeneration Of Cerebral Gray Matter With Hepatic Cirrhosis
Alpers Disease	Progressive Sclerosing Poliodystrophy
Pndc	Diffuse Cerebral Sclerosis Of Schilder
MTDPS4A	Neuronal Degeneration Of Childhood With Liver Disease, Progressive
Alper'S Syndrome	Alpers' Disease Or Gray-Matter Degeneration
Diffuse Cerebral Degeneration In Infancy	Infantile Poliodystrophy
Poliodystrophia Cerebri Progressiva	Progressive Cerebral Poliodystrophy
Alpers' Disease	Alpers Progressive Sclerosing Poliodystrophy
Progressive Neuronal Degeneration Of Childhood With Liver Disease	Ahs
Mitochondrial Dna Depletion Syndrome 4a Alpers Type	Neuronal Degeneration Of Childhood With Liver Disease Progressive

Combined Oxidative Phosphorylation Deficiency 1

Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1	COXPD1
Early Fatal Progressive Hepatoencephalopathy	Hepatoencephalopathy Due To Coxpd1
Combined Oxidative Phosphorylation Deficiency, Type 1	Hepatoencephalopathy, Early Fatal Progressive
Hepatoencephalopathy Early Fatal Progressive

Methylmalonic Acidemia

Methylmalonic Aciduria	Mma
Acidemia, Methylmalonic	Isolated Methylmalonic Acidemia

Developmental And Epileptic Encephalopathy 7

Epileptic Encephalopathy, Early Infantile, 7	DEE7
Eiee7	Kcnq2-Related Epileptic Encephalopathy
Kcnq2-Related Neonatal Epileptic Encephalopathy	Developmental And Epileptic Encephalopathy, 7
Early Infantile Epileptic Encephalopathy 7	Kcnq2-Nee
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile, Type 7
Early Infantile Epileptic Encephalopathy With Suppression Bursts

Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis

SANDO	Mitochondrial Recessive Ataxia Syndrome
Spinocerebellar Ataxia With Epilepsy	Epilepsy, Progressive Myoclonic 5
Epm5	Miras
SCAE	Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions, Autosomal Recessive
Autosomal Recessive Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions	Progressive Myoclonic Epilepsy Type 5
Pme Type 5	Progressive Myoclonus Epilepsy Type 5
Sensory Ataxic Neuropathy-Dysarthria-Ophthalmoparesis Syndrome	Recessive Mitochondrial Ataxia Syndrome
Sensory Ataxic Neuropathy Dysarthria And Ophthalmoparesis	Mitochondrial Spinocerebellar Ataxia-Epilepsy Syndrome
Mscae	Sensory Ataxic Neuropathy With Mitochondrial Dna Deletions Autosomal Recessive
Progressive Myoclonic Epilepsy With Sensory Ataxic Neuropathy	Epilepsy, Progressive Myoclonic, 5
Ataxia Neuropathy Spectrum

Organic Acidemia

Organic Aciduria	Disorder Of Organic Acid Metabolism
Organic Acid Metabolism Disorder	Organic Acidemias
Inherited Organic Acidemia	Organic Acidurias
Aciduria Organic

Chronic Progressive External Ophthalmoplegia

Progressive External Ophthalmoplegia	Cpeo
Peo	Ophthalmoplegia, Chronic Progressive External
Ophthalmoplegia, External, Progressive, Chronic	Graefe Disease
Peo - [Progressive External Ophthalmoplegia]	Ophthalmoplegia Plus Syndrome

3-Methylglutaconic Aciduria

3-Methyl Glutaconic Aciduria

Neuropathy, Ataxia, And Retinitis Pigmentosa

Narp Syndrome	NARP
Neurogenic Muscle Weakness, Ataxia, And Retinitis Pigmentosa	Neurogenic Muscle Weakness-Ataxia-Retinitis Pigmentosa Syndrome
Neuropathy-Ataxia-Retinitis Pigmentosa Syndrome	Neuropathy, Ataxia And Retinitis Pigmentosa
Neuropathy Ataxia Retinitis Pigmentosa Syndrome	Neuropathy, Ataxia, And Retinitis Pigmentos
Neuropathy Ataxia And Retinitis Pigmentosa	Neuropathy, Ataxia, Retinitis Pigmentosa
Neuropathy Ataxia And Retinis Pigmentosa	Narp - [Neuropathy, Ataxia And Retinitis Pigmentosa] Syndrome

Fatal Infantile Cardioencephalomyopathy Due To Cytochrome C Oxidase Deficiency

Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency	Fatal Infantile Cox Deficiency
Fatal Infantile Cytochrome C Oxidase Deficiency	Fatal Infantile Encephalocardiomyopathy

Mitochondrial Encephalomyopathy

Mitochondrial Encephalomyopathies

Encephalomyopathy, Mitochondrial

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14000	SUCLA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SUCLA2	VGNC	VGNC:102338
Canis familiaris	SUCLA2	VGNC	VGNC:54998
Rattus norvegicus	SUCLA2	RGD	RGD:1309397
Macaca mulatta	SUCLA2	VGNC	VGNC:103872
Mus musculus	SUCLA2	MGD	MGI:1306775
Bos taurus	SUCLA2	VGNC	VGNC:35455