CCNK - cyclin K Gene

Homo sapiens

Also known as CPR4; IDDHDF

Gene ID: 8812 | Gene type: protein coding

About CCNK

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,481,409-99,512,440 (from NCBI)

This gene has 9 transcripts (splice variants), 169 orthologues, 6 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 33.7), testis (RPKM 31.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

CCNK Products(1)

mRNA	Protein	Name
NM_001099402.2	NP_001092872.1	cyclin-K

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	9632813	GOA
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9632813	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22012619	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	22012619	GOA
involved in negative regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	21555514	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	22988298	GOA
involved in regulation of signal transduction	IDA IDA: Inferred from direct assay	26748711	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22988298	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cyclin K-CDK12 complex	IPI IPI: Inferred from physical interaction	22012619	GOA
part of cyclin K-CDK13 complex	IPI IPI: Inferred from physical interaction	22012619	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNK Protein Structure

Cyclin_N

0
100
200
300
400
500
580 a.a.

Protein Preferred Names

Protein Names

cyclin-K

CCNK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCNK	O75909	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	CCNK	O75909	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
Intra	CCNK	O75909	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	CCNK	O75909	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	CCNK	O75909	RBPMS	Homo sapiens	Q93062	Y2H Pooling	16189514
Intra	CCNK	O75909	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	CCNK	O75909	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	CCNK	O75909	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
Intra	CCNK	O75909	CDK13	Homo sapiens	Q14004	GMS	26748711
Intra	CCNK	O75909	CDK13	Homo sapiens	Q14004	X-Ray Diffraction	26748711

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Hypertelorism And Distinctive Facies

IDDHDF

Ccnk-Related Neurodevelopmental Disorder-Severe Intellectual Disability-Facial Dysmorphism Syndrome

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Kaposi'S Sarcoma-Associated Herpesvirus
Multiple Idiopathic Pigmented Hemangiosarcoma	Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To
African Lymphadenopathic Kaposi'S Sarcoma	Anal Kaposi'S Sarcoma
Cardiac Kaposi'S Sarcoma	Central Nervous System Kaposi'S Sarcoma
Conjunctival Kaposi'S Sarcoma	Corneal Kaposi'S Sarcoma
Cutaneous Kaposi'S Sarcoma	Esophageal Kaposi'S Sarcoma
Gallbladder Kaposi'S Sarcoma	Gastric Kaposi'S Sarcoma
Intestinal Kaposi'S Sarcoma	Kaposi'S Sarcoma Of Anus
Kaposi'S Sarcoma Of Central Nervous System	Kaposi'S Sarcoma Of Conjunctiva
Kaposi'S Sarcoma Of Cornea	Kaposi'S Sarcoma Of Esophagus
Kaposi'S Sarcoma Of Gastrointestinal Sites	Kaposi'S Sarcoma Of Heart
Kaposi'S Sarcoma Of Lymph Nodes	Kaposi'S Sarcoma Of Penis
Kaposi'S Sarcoma Of Skin	Kaposi'S Sarcoma Of Soft Tissues
Kaposi'S Sarcoma Of The Cns	Kaposi'S Sarcoma Of The Gallbladder
Kaposi'S Sarcoma Of The Prostate	Kaposi'S Sarcoma, Lung
Kaposi'S Sarcoma, Skin	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder

CHDFIDD	Cdk13-Related Disorder
Cdk13-Related Chdfidd	Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder

Developmental And Epileptic Encephalopathy 66

DEE66	Epileptic Encephalopathy, Early Infantile, 66
Eiee66	Developmental And Epileptic Encephalopathy, 66
Early Infantile Epileptic Encephalopathy 66	Encephalopathy, Epileptic, Early Infantile, Type 66

Corneal Endothelial Dystrophy

Congenital Hereditary Endothelial Dystrophy Of Cornea	Chandler Syndrome
CHED	Chandler'S Syndrome
Endothelial Corneal Dystrophy	Ched2
Maumenee Corneal Dystrophy	Corneal Dystrophy, Congenital Hereditary Endothelial
Dystrophy Of Corneal Endothelium	Corneal Endothelial Dystrophy 2
Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly	Ched2, Formerly
Corneal Endothelial Dystrophy, Autosomal Recessive	Endothelial Dystrophy
Posterior Membrane Corneal Dystrophy	Corneal Endothelial Dystrophy Type 2
Congenital Hereditary Endothelial Dystrophy Of The Cornea	Congenital Hereditary Endothelial Dystrophy Type Ii
Autosomal Recessive Ched	Autosomal Recessive Congenital Hereditary Endothelial Dystrophy
Chedii	Congenital Hereditary Endothelial Dystrophy Type 2
Infantile Hereditary Endothelial Dystrophy	Congenital Hereditary Endothelial Corneal Dystrophy
Corneal Endothelial Dystrophy 2, Autosomal Recessive	Iridocorneal Endothelial Syndrome
Dystrophy, Corneal, Endothelial	Corneal Endothelial Dystrophy 1, Autosomal Dominant

Intellectual Developmental Disorder, Autosomal Dominant 13

MRD13	Mental Retardation, Autosomal Dominant 13
Mental Retardation, Autosomal Dominant 13, With Neuronal Migration Defects	Autosomal Dominant Non-Syndromic Intellectual Disability 13
Autosomal Dominant Intellectual Developmental Disorder 13	Autosomal Dominant Mental Retardation 13
Mental Retardation, Autosomal Dominant, Type 13

Hypertelorism

Eyes Wide Apart	Eyes Widely Set
Hypertelorism Of Orbit	Ocular Hypertelorism
Orbital Separation Excessive

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W181530	NCT02	Degrader	98.14%	Unkown
HY-148523	HQ005	Degrader	99.51%	Unkown
HY-RS02135	CCNK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCNK	MGD	MGI:1276106
Rattus norvegicus	CCNK	RGD	RGD:1595690
Macaca mulatta	CCNK	VGNC	VGNC:70734
Bos taurus	CCNK	VGNC	VGNC:26974
Felis catus	CCNK	VGNC	VGNC:60565
Canis familiaris	CCNK	VGNC	VGNC:38904
Others	CCNK	NCBI

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