2. Gene
  3. TNFSF18 - TNF superfamily member 18 Gene

TNFSF18 - TNF superfamily member 18 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TL6; AITRL; GITRL; TNLG2A; hGITRL

Gene ID: 8995 | Gene type: protein coding

About TNFSF18

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,039,202-173,050,941 (from NCBI)

This gene has 1 transcript (splice variant) and 83 orthologues. Broad expression in gall bladder (RPKM 1.2), brain (RPKM 1.0) and 16 other tissues.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

TNFSF18 Products(1)

mRNA Protein Name
NM_005092.4 NP_005083.3 tumor necrosis factor ligand superfamily member 18
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18040044 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18040044 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
23892569 GOA
involved in positive regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
23892569 GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
23892569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFSF18 Protein Structure

TNF

TNF: TNF(Tumour Necrosis Factor) family (103 - 192)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 18

AITR ligand

Recombinant TNFSF18 Proteins

Cat. No. Product Name Accession Purity
HY-P7318 AITRL/TNFSF18 Protein, Human Q9UNG2 (E52-I176) ≥95%
HY-P74503 AITRL/TNFSF18 Protein, Human (sf9, His) Q9UNG2/AAD22634 (E52-S177) ≥95%
HY-P76110 AITRL/TNFSF18 Protein, Human (HEK293, Fc) Q9UNG2/NP_005083.3 (Q50-S177) ≥95%
HY-P78133 AITRL/TNFSF18 Trimer Protein, Human (Biotinylated, HEK293, His-Flag) Q9UNG2 (Q50-S177) ≥95%
HY-P78448 AITRL/TNFSF18 Trimer Protein, Human (HEK293, His-Flag) Q9UNG2 (Q50-S177) ≥95%
HY-P700014AF Animal-Free AITRL/TNFSF18 Protein, Human (His) Q9UNG2 (Q49-I174) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14827 TNFSF18 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TNFSF18 VGNC VGNC:36175
Felis catus TNFSF18 VGNC VGNC:107953
Canis familiaris TNFSF18 VGNC VGNC:53841
Macaca mulatta TNFSF18 VGNC VGNC:78597
Mus musculus TNFSF18 MGD MGI:2673064
Rattus norvegicus TNFSF18 RGD RGD:1305066
Macaca fascicularis TNFSF18 NCBI NCBI:102140808
Others TNFSF18 NCBI