2. Gene
  3. NAT8 - N-acetyltransferase 8 (putative) Gene

NAT8 - N-acetyltransferase 8 (putative) Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GLA; CML1; CCNAT; Hcml1; ATase2; TSC501; TSC510

Gene ID: 9027 | Gene type: protein coding

About NAT8

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,640,723-73,642,422 (from NCBI)

This gene has 1 transcript (splice variant), 344 orthologues and 3 paralogues. Restricted expression toward kidney (RPKM 344.5).

Summary

This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq, Sep 2008]

NAT8 Products(1)

mRNA Protein Name
NM_003960.4 NP_003951.3 N-acetyltransferase 8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-S-conjugate N-acetyltransferase activity IDA
IDA: Inferred from direct assay
20392701 GOA
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
IDA: Inferred from direct assay
19011241 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19011241 GOA
Biological Process GO Annotation Evidence Reference Source
involved in peptidyl-lysine N6-acetylation IDA
IDA: Inferred from direct assay
19011241 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19011241 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
20392701 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
24556617 GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
IDA: Inferred from direct assay
19011241 GOA
located in membrane IDA
IDA: Inferred from direct assay
20392701 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAT8 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (112 - 194)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

N-acetyltransferase 8

N-acetyltransferase 8 (GCN5-related, putative)

NAT8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NAT8 Q9UHE5 REEP2 Homo sapiens Q9BRK0
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 REEP2 Homo sapiens Q9BRK0
Y2H Array
32296183
Intra NAT8 Q9UHE5 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra NAT8 Q9UHE5 ATP6V0E1 Homo sapiens O15342
Y2H Array
32296183
Intra NAT8 Q9UHE5 ATP6V0E1 Homo sapiens O15342
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra NAT8 Q9UHE5 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 TMEM143 Homo sapiens Q96AN5
Y2H Array
32296183
Intra NAT8 Q9UHE5 TMEM143 Homo sapiens Q96AN5
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra NAT8 Q9UHE5 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra NAT8 Q9UHE5 TSPAN31 Homo sapiens Q12999
Y2H Array
32296183
Intra NAT8 Q9UHE5 TSPAN31 Homo sapiens Q12999
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra NAT8 Q9UHE5 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra NAT8 Q9UHE5 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra NAT8 Q9UHE5 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra NAT8 Q9UHE5 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra NAT8 Q9UHE5 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra NAT8 Q9UHE5 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra NAT8 Q9UHE5 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra NAT8 Q9UHE5 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra NAT8 Q9UHE5 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 JPH1 Homo sapiens Q9HDC5
Y2H Array
32296183
Intra NAT8 Q9UHE5 JPH1 Homo sapiens Q9HDC5
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra NAT8 Q9UHE5 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra NAT8 Q9UHE5 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra NAT8 Q9UHE5 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra NAT8 Q9UHE5 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 YIPF4 Homo sapiens Q9BSR8
Y2H Array
32296183
Intra NAT8 Q9UHE5 YIPF4 Homo sapiens Q9BSR8
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra NAT8 Q9UHE5 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra NAT8 Q9UHE5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra NAT8 Q9UHE5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Iminoglycinuria

Iminoglycinuria, Digenic

IG
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09043 NAT8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09044 NAT8L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NAT8 MGD MGI:1915646
Rattus norvegicus NAT8 RGD RGD:621609