SPAG9 - sperm associated antigen 9 Gene

Homo sapiens

Also known as JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4

Gene ID: 9043 | Gene type: protein coding

About SPAG9

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,962,174-51,120,868 (from NCBI)

This gene has 21 transcripts (splice variants), 289 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 29.0), testis (RPKM 27.0) and 25 other tissues.

Summary

This gene encodes a member of the Cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

SPAG9 Products(4)

mRNA	Protein	Name
NM_001130527.3	NP_001123999.1	C-Jun-amino-terminal kinase-interacting protein 4 isoform 2
NM_001130528.3	NP_001124000.1	C-Jun-amino-terminal kinase-interacting protein 4 isoform 1
NM_001251971.2	NP_001238900.1	C-Jun-amino-terminal kinase-interacting protein 4 isoform 4
NM_003971.6	NP_003962.3	C-Jun-amino-terminal kinase-interacting protein 4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19644450	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	29146937	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18826971	GOA
acts upstream of or within retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	19056739	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosomal membrane	IDA IDA: Inferred from direct assay	29146937	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPAG9 Protein Structure

Jnk-SapK_ap_N

0
300
600
900
1200
1321 a.a.

Protein Preferred Names

Protein Names

C-Jun-amino-terminal kinase-interacting protein 4

JNK interacting protein

Related Diseases

Diseases

Alias

Infertility

Retinitis Pigmentosa 42

RP42	Retinitis Pigmentosa-42
Retinitis Pigmentosa, Type 42

Subacute Leukemia

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13627	SPAG9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPAG9	VGNC	VGNC:35170
Mus musculus	SPAG9	MGD	MGI:1918084
Felis catus	SPAG9	VGNC	VGNC:65599
Rattus norvegicus	SPAG9	RGD	RGD:1311289
Canis familiaris	SPAG9	VGNC	VGNC:46699
Macaca mulatta	SPAG9	VGNC	VGNC:77920

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