DNAJA3 - DnaJ heat shock protein family (Hsp40) member A3 Gene

Homo sapiens

Also known as TID1; HCA57; hTID-1

Gene ID: 9093 | Gene type: protein coding

About DNAJA3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,425,868-4,456,775 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 282 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 19.3), kidney (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a member of the DNAJ/HSP40 protein family. DNAJ/HSP40 proteins stimulate the ATPase activity of HSP70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

DNAJA3 Products(3)

mRNA	Protein	Name
NM_001135110.3	NP_001128582.1	dnaJ homolog subfamily A member 3, mitochondrial isoform 2
NM_001286516.2	NP_001273445.1	dnaJ homolog subfamily A member 3, mitochondrial isoform 3
NM_005147.6	NP_005138.3	dnaJ homolog subfamily A member 3, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	21106534	GOA
enables IkappaB kinase complex binding	IDA IDA: Inferred from direct assay	15601829	GOA
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	15601829	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16531398	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10411904	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11679576	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15601829	GOA
enables type II interferon receptor binding	IDA IDA: Inferred from direct assay	11679576	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	10411904	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11927590	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10411904	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11927590	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11719219	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	10411904	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	15601829	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21106534	GOA
involved in negative regulation of type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	11679576	GOA
involved in neuromuscular junction development	IDA IDA: Inferred from direct assay	19038220	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10411904	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	15520177	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	16531398	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	11927590	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	11679576	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	17588722	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11679576	GOA
located in cytosol	IMP IMP: Inferred from mutant phenotype	16531398	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	10411904	GOA
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	16531398	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20053669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11679576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJA3 Protein Structure

DnaJ

DnaJ_CXXCXGXG

DnaJ_C

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily A member 3, mitochondrial

DnaJ (Hsp40) homolog, subfamily A, member 3

DNAJA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNAJA3	Q96EY1	STAT5B	Homo sapiens	P51692	Anti Bait CoIP	21106534
Cross	DNAJA3	Q96EY1	Ptch1	Mus musculus	Q61115	Anti Bait CoIP	17230190
Cross	DNAJA3	Q96EY1	Ptch1	Mus musculus	Q61115	Anti Tag CoIP	17230190
Intra	DNAJA3	Q96EY1	CARM1	Homo sapiens	Q86X55	Anti Tag CoIP	23455924
Intra	DNAJA3	Q96EY1	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	DNAJA3	Q96EY1	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	DNAJA3	Q96EY1	HTT	Homo sapiens	P42858	Y2H	17500595
Cross	DNAJA3	Q96EY1	Stat5b	Mus musculus	P42232	Y2H	21106534
Intra	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	DNAJA3	Q96EY1	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	DNAJA3	Q96EY1	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	DNAJA3	Q96EY1	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
Intra	DNAJA3	Q96EY1	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924
Intra	DNAJA3	Q96EY1	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924
Intra	DNAJA3	Q96EY1	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myasthenic Syndrome, Congenital, 12

Congenital Myasthenic Syndrome 12	CMS12
Myasthenic Syndrome, Congenital, With Tubular Aggregates 1	Cmsta1
Myasthenia, Congenital, 12, With Tubular Aggregates	Congenital Myasthenia 12 With Tubular Aggregates
Limb-Girdle Myasthenia With Tubular Aggregates	Myasthenia, Congenital, With Tubular Aggregates 1
Myasthenic Syndrome, Congenital, With Tubular Aggregates, 1

Alternating Esotropia

Codas Syndrome

Cerebral, Ocular, Dental, Auricular, And Skeletal Anomalies Syndrome	Cerebral, Ocular, Dental, Auricular, And Skeletal Syndrome
Cerebro-Oculo-Dento-Auriculo-Skeletal Syndrome	Cerebrooculodentoauriculoskeletal Syndrome
CODASS	Cerebral, Ocular, Dental, Auricular, Skeletal Syndrome

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Congenital Myasthenic Syndrome

Congenital Myasthenia	Congenital Myasthenic Syndromes
Cms	Myasthenic Syndromes, Congenital
Myasthenic Syndromes Congenital	Myasthenic Syndrome, Congenital
Congenital Myasthenic Syndrome Ib	Congenital And Developmental Myasthenia
Developmental Myasthenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03859	DNAJA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNAJA3	VGNC	VGNC:99506
Felis catus	DNAJA3	VGNC	VGNC:80564
Mus musculus	DNAJA3	MGD	MGI:1933786
Rattus norvegicus	DNAJA3	RGD	RGD:1306527
Canis familiaris	DNAJA3	VGNC	VGNC:49081

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