MAGI1 - membrane associated guanylate kinase, WW and PDZ domain containing 1 Gene

Homo sapiens

Also known as AIP3; BAP1; WWP3; AIP-3; BAP-1; BAIAP1; MAGI-1; Magi1d; TNRC19; MAGI-1b

Gene ID: 9223 | Gene type: protein coding

About MAGI1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:65,353,526-66,038,918 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 288 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 5.4), brain (RPKM 4.9) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

MAGI1 Products(6)

mRNA	Protein	Name
NM_001033057.2	NP_001028229.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c
NM_001365903.2	NP_001352832.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d
NM_001365904.2	NP_001352833.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform e
NM_001365905.1	NP_001352834.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform f
NM_004742.3	NP_004733.2	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform b
NM_015520.2	NP_056335.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-actinin binding	IPI IPI: Inferred from physical interaction	16464232	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9647693	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	20298433	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell periphery	IDA IDA: Inferred from direct assay	20298433	GOA
located in cell projection	IDA IDA: Inferred from direct assay	16464232	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	20298433	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16464232	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20298433	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGI1 Protein Structure

Guanylate_kin

PDZ

0
300
600
900
1200
1462 a.a.

Protein Preferred Names

Protein Names

membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

BAI1-associated protein 1

Related Diseases

Diseases

Alias

Cervical Large Cell Neuroendocrine Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07981	MAGI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAGI1	RGD	RGD:1586025
Macaca mulatta	MAGI1	VGNC	VGNC:74499
Bos taurus	MAGI1	VGNC	VGNC:31147
Mus musculus	MAGI1	MGD	MGI:1203522
Felis catus	MAGI1	VGNC	VGNC:69081
Canis familiaris	MAGI1	VGNC	VGNC:108248
Others	MAGI1	NCBI

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