FCHSD2 - FCH and double SH3 domains 2 Gene

Homo sapiens

Also known as NWK; NWK1; SH3MD3

Gene ID: 9873 | Gene type: protein coding

About FCHSD2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,836,745-73,142,318 (from NCBI)

This gene has 9 transcripts (splice variants), 287 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 18.6), lymph node (RPKM 17.3) and 25 other tissues.

Summary

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in plasma membrane. Colocalizes with clathrin-coated pit. [provided by Alliance of Genome Resources, Apr 2022]

FCHSD2 Products(1)

mRNA	Protein	Name
NM_014824.3	NP_055639.2	F-BAR and double SH3 domains protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	29887380	GOA
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	29887380	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14627983	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	29887380	GOA
involved in positive regulation of Arp2/3 complex-mediated actin nucleation	IMP IMP: Inferred from mutant phenotype	29887380	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with clathrin-coated pit	IDA IDA: Inferred from direct assay	29887380	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	29887380	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCHSD2 Protein Structure

FCH

SH3_1

SH3_9

0
200
400
600
740 a.a.

Protein Preferred Names

Protein Names

F-BAR and double SH3 domains protein 2

FCH and double SH3 domains protein 2

FCHSD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FCHSD2	O94868	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
Intra	FCHSD2	O94868	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	FCHSD2	O94868	VCP	Homo sapiens	P55072	Anti Tag CoIP	18654987
Intra	FCHSD2	O94868	ABCF3	Homo sapiens	Q9NUQ8	Y2H Array	31515488
Intra	FCHSD2	O94868	ABCF3	Homo sapiens	Q9NUQ8	Validated Y2H	25416956
Intra	FCHSD2	O94868	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	FCHSD2	O94868	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	FCHSD2	O94868	MAGI1	Homo sapiens	Q96QZ7	Anti Tag CoIP	14627983
Intra	FCHSD2	O94868	MAGI1	Homo sapiens	Q96QZ7	Pull Down	14627983
Cross	FCHSD2	O94868	Cask	Rattus norvegicus	Q62915	Pull Down	14627983

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease 14

AD14	Alzheimer'S Disease 14
Alzheimer Disease-14	Alzheimer'S Disease 14, Late Onset

Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis

Inflammatory Bowel Disease 9

IBD9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04837	FCHSD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FCHSD2	MGD	MGI:2448475
Canis familiaris	FCHSD2	VGNC	VGNC:40807
Macaca mulatta	FCHSD2	VGNC	VGNC:72593
Felis catus	FCHSD2	VGNC	VGNC:62213
Rattus norvegicus	FCHSD2	RGD	RGD:1304812
Bos taurus	FCHSD2	VGNC	VGNC:28937

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