MOB1B - MOB kinase activator 1B Gene

Homo sapiens

Also known as MATS2; MOB4A; MOBKL1A

Gene ID: 92597 | Gene type: protein coding

About MOB1B

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,901,851-70,988,168 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 6 paralogues. Ubiquitous expression in kidney (RPKM 9.7), bone marrow (RPKM 8.6) and 25 other tissues.

Summary

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

MOB1B Products(3)

mRNA	Protein	Name
NM_001244766.2	NP_001231695.1	MOB kinase activator 1B isoform 1
NM_001244767.2	NP_001231696.1	MOB kinase activator 1B isoform 3
NM_173468.4	NP_775739.1	MOB kinase activator 1B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase activator activity	IDA IDA: Inferred from direct assay	15197186	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	15197186	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19739119	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	18328708	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	18328708	GOA
involved in regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	15197186	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	18328708	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15067004	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15067004	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB1B Protein Structure

Mob1_phocein

0
100
200
216 a.a.

Protein Preferred Names

Protein Names

MOB kinase activator 1B

MOB1 Mps One Binder homolog B

MOB1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MOB1B	Q7L9L4	LATS2	Homo sapiens	Q9NRM7	Anti Tag CoIP	33961781
Intra	MOB1B	Q7L9L4	LATS2	Homo sapiens	Q9NRM7	Anti Tag CoIP	28514442
Intra	MOB1B	Q7L9L4	LATS2	Homo sapiens	Q9NRM7	BioID	24255178
Intra	MOB1B	Q7L9L4	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	MOB1B	Q7L9L4	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24255178
Intra	MOB1B	Q7L9L4	STK4	Homo sapiens	Q13043	Protein Kinase Assay	22863277
Intra	MOB1B	Q7L9L4	STK4	Homo sapiens	Q13043	BioID	24255178
Intra	MOB1B	Q7L9L4	LATS1	Homo sapiens	O95835	Anti Tag CoIP	19739119
Intra	MOB1B	Q7L9L4	LATS1	Homo sapiens	O95835	Anti Tag CoIP	28514442
Intra	MOB1B	Q7L9L4	LATS1	Homo sapiens	O95835	BioID	24255178
Intra	MOB1B	Q7L9L4	LATS1	Homo sapiens	O95835	Anti Tag CoIP	33961781
Intra	MOB1B	Q7L9L4	LATS1	Homo sapiens	O95835	Anti Tag CoIP	24255178
Intra	MOB1B	Q7L9L4	LATS1	Homo sapiens	O95835	Anti Tag CoIP	24366813
Intra	MOB1B	Q7L9L4	NT5C2	Homo sapiens	P49902	Y2H Prey Pooling	25416956
Intra	MOB1B	Q7L9L4	NT5C2	Homo sapiens	P49902	Validated Y2H	25416956
Intra	MOB1B	Q7L9L4	NT5C2	Homo sapiens	P49902	Y2H Array	25416956
Intra	MOB1B	Q7L9L4	STK3	Homo sapiens	Q13188	BioID	24255178
Intra	MOB1B	Q7L9L4	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24255178

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MOB1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77449	MOB4A/MOB1B Protein, Human (His)	Q7L9L4-1 (M1-R216)	≥95%

Related Diseases

Diseases

Alias

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08574	MOB1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MOB1B	VGNC	VGNC:43300
Macaca mulatta	MOB1B	VGNC	VGNC:74863
Rattus norvegicus	MOB1B	RGD	RGD:1305114
Mus musculus	MOB1B	MGD	MGI:1915723
Felis catus	MOB1B	VGNC	VGNC:63544
Bos taurus	MOB1B	VGNC	VGNC:31542
Others	MOB1B	NCBI

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