HNRNPLL - heterogeneous nuclear ribonucleoprotein L like Gene

Homo sapiens

Also known as SRRF; HNRPLL

Gene ID: 92906 | Gene type: protein coding

About HNRNPLL

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,561,969-38,602,928 (from NCBI)

This gene has 12 transcripts (splice variants), 275 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 17.8), thyroid (RPKM 11.5) and 25 other tissues.

Summary

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine Phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

HNRNPLL Products(2)

mRNA	Protein	Name
NM_001142650.2	NP_001136122.1	heterogeneous nuclear ribonucleoprotein L-like isoform 2
NM_138394.4	NP_612403.2	heterogeneous nuclear ribonucleoprotein L-like isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	18669861	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18669861	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of RNA splicing	IDA IDA: Inferred from direct assay	18669861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPLL Protein Structure

RRM_5

0
100
200
300
400
500
542 a.a.

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein L-like

stromal RNA regulating factor

HNRNPLL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	HNRNPLL	Q8WVV9	P0DTD1-PRO_0000449620	SARS-CoV-2	P0DTD1-PRO_0000449620	BLI	34159380
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978	Y2H Array	29892012
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	HNRNPLL	Q8WVV9	RHOXF2	Homo sapiens	Q9BQY4	Validated Y2H	25416956
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	26871637
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978-2	Y2H Array	26871637
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	26871637
Intra	HNRNPLL	Q8WVV9	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	HNRNPLL	Q8WVV9	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	HNRNPLL	Q8WVV9	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	25416956
Intra	HNRNPLL	Q8WVV9	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	25416956
Intra	HNRNPLL	Q8WVV9	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	HNRNPLL	Q8WVV9	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
Intra	HNRNPLL	Q8WVV9	DAB1	Homo sapiens	O75553	Y2H Array	25416956
Intra	HNRNPLL	Q8WVV9	QKI	Homo sapiens	Q96PU8	Anti Tag CoIP	33961781
Intra	HNRNPLL	Q8WVV9	QKI	Homo sapiens	Q96PU8	Validated Y2H	25416956
Intra	HNRNPLL	Q8WVV9	BOLL	Homo sapiens	Q8N9W6	Y2H Array	31515488
Intra	HNRNPLL	Q8WVV9	BOLL	Homo sapiens	Q8N9W6	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06275	HNRNPLL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HNRNPLL	MGD	MGI:1919942
Bos taurus	HNRNPLL	VGNC	VGNC:29898
Rattus norvegicus	HNRNPLL	RGD	RGD:1305861
Canis familiaris	HNRNPLL	VGNC	VGNC:41733
Felis catus	HNRNPLL	VGNC	VGNC:62827
Macaca mulatta	HNRNPLL	VGNC	VGNC:73441

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