2. Gene
  3. HNRNPLL - heterogeneous nuclear ribonucleoprotein L like Gene

HNRNPLL - heterogeneous nuclear ribonucleoprotein L like Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SRRF; HNRPLL

Gene ID: 92906 | Gene type: protein coding

About HNRNPLL

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,561,969-38,602,928 (from NCBI)

This gene has 12 transcripts (splice variants), 275 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 17.8), thyroid (RPKM 11.5) and 25 other tissues.

Summary

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine Phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

HNRNPLL Products(2)

mRNA Protein Name
NM_001142650.2 NP_001136122.1 heterogeneous nuclear ribonucleoprotein L-like isoform 2
NM_138394.4 NP_612403.2 heterogeneous nuclear ribonucleoprotein L-like isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables mRNA binding IDA
IDA: Inferred from direct assay
18669861 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18669861 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of RNA splicing IDA
IDA: Inferred from direct assay
18669861 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPLL Protein Structure

(78 - 130)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (185 - 242)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (352 - 407)

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  • 542 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein L-like

stromal RNA regulating factor

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06275 HNRNPLL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HNRNPLL MGD MGI:1919942
Bos taurus HNRNPLL VGNC VGNC:29898
Rattus norvegicus HNRNPLL RGD RGD:1305861
Canis familiaris HNRNPLL VGNC VGNC:41733
Felis catus HNRNPLL VGNC VGNC:62827
Macaca mulatta HNRNPLL VGNC VGNC:73441