COPS2 - COP9 signalosome subunit 2 Gene

Homo sapiens

Also known as CSN2; SGN2; ALIEN; TRIP15

Gene ID: 9318 | Gene type: protein coding

About COPS2

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:49,122,727-49,155,599 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 22.3), thyroid (RPKM 19.6) and 25 other tissues.

Summary

Predicted to enable transcription corepressor activity. Involved in protein deneddylation and protein phosphorylation. Located in cytoplasm. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

COPS2 Products(2)

mRNA	Protein	Name
NM_001143887.2	NP_001137359.1	COP9 signalosome complex subunit 2 isoform 2
NM_004236.4	NP_004227.1	COP9 signalosome complex subunit 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17438371	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein deneddylation	IDA IDA: Inferred from direct assay	19141280	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9535219	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	9535219	GOA
part of COP9 signalosome	IPI IPI: Inferred from physical interaction	25043011	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9535219	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24421388	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS2 Protein Structure

PCI

0
100
200
300
400
443 a.a.

Protein Preferred Names

Protein Names

COP9 signalosome complex subunit 2

COP9 constitutive photomorphogenic homolog subunit 2

COPS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COPS2	P61201	GPS1	Homo sapiens	Q13098-7	Y2H Prey Pooling	32296183
Intra	COPS2	P61201	GPS1	Homo sapiens	Q13098-7	Validated Y2H	32296183
Intra	COPS2	P61201	GPS1	Homo sapiens	Q13098-7	Y2H Array	32296183
Intra	COPS2	P61201	GPS1	Homo sapiens	Q13098-7	X-Ray Diffraction	25043011
Intra	COPS2	P61201	GPS1	Homo sapiens	Q13098-7	GMS	25043011
Cross	COPS2	P61201	Crebbp	Mus musculus	P45481	Pull Down	23441852
Intra	COPS2	P61201	COPS3	Homo sapiens	Q9UNS2	GMS	25043011
Intra	COPS2	P61201	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	33961781
Intra	COPS2	P61201	COPS3	Homo sapiens	Q9UNS2	X-Ray Diffraction	25043011
Intra	COPS2	P61201	PSMD11	Homo sapiens	O00231	Y2H Prey Pooling	32296183
Intra	COPS2	P61201	PSMD11	Homo sapiens	O00231	Y2H Array	32296183
Intra	COPS2	P61201	EP300	Homo sapiens	Q09472	Acetylase Assay	23441852
Intra	COPS2	P61201	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	COPS2	P61201	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	COPS2	P61201	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	COPS2	P61201	ZNF446	Homo sapiens	Q9NWS9-2	Validated Y2H	32296183
Intra	COPS2	P61201	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
Intra	COPS2	P61201	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
Intra	COPS2	P61201	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
Intra	COPS2	P61201	CREBBP	Homo sapiens	Q92793	Anti Bait CoIP	23441852
Cross	COPS2	P61201	P29991-PRO_0000037946	Dengue virus type 2	P29991-PRO_0000037946	Y2H	21911577
Cross	COPS2	P61201	P29991-PRO_0000037946	Dengue virus type 2	P29991-PRO_0000037946	Split-Luc	21911577

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03027	COPS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	COPS2	VGNC	VGNC:39509
Macaca mulatta	COPS2	VGNC	VGNC:71376
Mus musculus	COPS2	MGD	MGI:1330276
Bos taurus	COPS2	VGNC	VGNC:27599
Rattus norvegicus	COPS2	RGD	RGD:628791
Felis catus	COPS2	VGNC	VGNC:61087

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