COPS3 - COP9 signalosome subunit 3 Gene

Homo sapiens

Also known as CSN3; SGN3

Gene ID: 8533 | Gene type: protein coding

About COPS3

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,246,616-17,281,246 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.1), bone marrow (RPKM 38.5) and 25 other tissues.

Summary

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

COPS3 Products(7)

mRNA	Protein	Name
NM_001199125.1	NP_001186054.1	COP9 signalosome complex subunit 3 isoform 2
NM_001316354.2	NP_001303283.1	COP9 signalosome complex subunit 3 isoform 3
NM_001316355.2	NP_001303284.1	COP9 signalosome complex subunit 3 isoform 4
NM_001316356.2	NP_001303285.1	COP9 signalosome complex subunit 3 isoform 5
NM_001316357.2	NP_001303286.1	COP9 signalosome complex subunit 3 isoform 6
NM_001316358.2	NP_001303287.1	COP9 signalosome complex subunit 3 isoform 6
NM_003653.4	NP_003644.2	COP9 signalosome complex subunit 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10777491	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein deneddylation	IDA IDA: Inferred from direct assay	19141280	GOA
involved in regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP IMP: Inferred from mutant phenotype	15861129	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
part of COP9 signalosome	IPI IPI: Inferred from physical interaction	25043011	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24421388	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24421388	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15861129	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS3 Protein Structure

PCI

0
100
200
300
400
423 a.a.

Protein Preferred Names

Protein Names

COP9 signalosome complex subunit 3

COP9 complex subunit 3

COPS3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COPS3	Q9UNS2	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	COPS3	Q9UNS2	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	COPS3	Q9UNS2	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	COPS2	Homo sapiens	P61201	Pull Down	25043011
Intra	COPS3	Q9UNS2	COPS2	Homo sapiens	P61201	Anti Tag CoIP	24421388
Intra	COPS3	Q9UNS2	COPS2	Homo sapiens	P61201	Anti Bait CoIP	24421388
Intra	COPS3	Q9UNS2	COPS2	Homo sapiens	P61201	Pull Down	20399188
Intra	COPS3	Q9UNS2	COPS2	Homo sapiens	P61201	Anti Tag CoIP	33961781
Intra	COPS3	Q9UNS2	RAB7A	Homo sapiens	P51149	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	RAB7A	Homo sapiens	P51149	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	RAB7A	Homo sapiens	P51149	Y2H Array	32814053
Intra	COPS3	Q9UNS2	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	COPS3	Q9UNS2	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	ERCC8	Homo sapiens	Q13216-2	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	ERCC8	Homo sapiens	Q13216-2	Y2H Array	32814053
Intra	COPS3	Q9UNS2	ERCC8	Homo sapiens	Q13216-2	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	COPS3	Q9UNS2	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	COPS8	Homo sapiens	Q99627	Pull Down	25043011
Intra	COPS3	Q9UNS2	COPS8	Homo sapiens	Q99627	Pull Down	20399188
Intra	COPS3	Q9UNS2	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	COPS3	Q9UNS2	PANK2	Homo sapiens	Q9BZ23-2	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	PANK2	Homo sapiens	Q9BZ23-2	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	PANK2	Homo sapiens	Q9BZ23-2	Y2H Array	32814053
Intra	COPS3	Q9UNS2	TTBK2	Homo sapiens	Q6IQ55-3	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	TTBK2	Homo sapiens	Q6IQ55-3	Y2H Array	32814053
Intra	COPS3	Q9UNS2	TTBK2	Homo sapiens	Q6IQ55-3	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	SOS1	Homo sapiens	Q07889	Y2H	30631038
Intra	COPS3	Q9UNS2	SOS1	Homo sapiens	Q07889	Pull Down	30631038
Intra	COPS3	Q9UNS2	DDB1	Homo sapiens	Q16531	Anti Tag CoIP	33961781
Intra	COPS3	Q9UNS2	DDB1	Homo sapiens	Q16531	Y2H	10777491
Intra	COPS3	Q9UNS2	LMNA	Homo sapiens	P02545-2	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	LMNA	Homo sapiens	P02545-2	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	LMNA	Homo sapiens	P02545-2	Y2H Array	32814053
Intra	COPS3	Q9UNS2	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	COPS3	Q9UNS2	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	COPS3	Q9UNS2	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	COPS3	Q9UNS2	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	COPS6	Homo sapiens	Q7L5N1	Anti Tag CoIP	24421388
Intra	COPS3	Q9UNS2	COPS6	Homo sapiens	Q7L5N1	Anti Tag CoIP	33961781
Intra	COPS3	Q9UNS2	COPS6	Homo sapiens	Q7L5N1	Pull Down	25043011
Intra	COPS3	Q9UNS2	COPS6	Homo sapiens	Q7L5N1	Anti Bait CoIP	24421388
Intra	COPS3	Q9UNS2	COPS6	Homo sapiens	Q7L5N1	Pull Down	20399188
Intra	COPS3	Q9UNS2	TOR1A	Homo sapiens	O14656	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	TOR1A	Homo sapiens	O14656	Y2H Array	32814053
Intra	COPS3	Q9UNS2	TOR1A	Homo sapiens	O14656	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	COPS5	Homo sapiens	Q92905	Pull Down	25043011
Intra	COPS3	Q9UNS2	COPS5	Homo sapiens	Q92905	Anti Tag CoIP	24421388
Intra	COPS3	Q9UNS2	COPS5	Homo sapiens	Q92905	Anti Bait CoIP	24421388
Intra	COPS3	Q9UNS2	COPS5	Homo sapiens	Q92905	Pull Down	20399188
Intra	COPS3	Q9UNS2	COPS5	Homo sapiens	Q92905	Anti Tag CoIP	33961781
Intra	COPS3	Q9UNS2	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	COPS3	Q9UNS2	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053
Intra	COPS3	Q9UNS2	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	COPS3	Q9UNS2	COPS7A	Homo sapiens	Q9UBW8	Anti Bait CoIP	24421388
Intra	COPS3	Q9UNS2	COPS7A	Homo sapiens	Q9UBW8	Pull Down	20399188
Intra	COPS3	Q9UNS2	COPS7A	Homo sapiens	Q9UBW8	Anti Tag CoIP	28514442
Intra	COPS3	Q9UNS2	COPS7A	Homo sapiens	Q9UBW8	Anti Tag CoIP	33961781
Intra	COPS3	Q9UNS2	COPS7A	Homo sapiens	Q9UBW8	Pull Down	25043011
Intra	COPS3	Q9UNS2	HEXB	Homo sapiens	P07686	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	HEXB	Homo sapiens	P07686	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	HEXB	Homo sapiens	P07686	Y2H Array	32814053
Intra	COPS3	Q9UNS2	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	COPS3	Q9UNS2	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	COPS3	Q9UNS2	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	PHYH	Homo sapiens	O14832	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	PHYH	Homo sapiens	O14832	Y2H Array	32814053
Intra	COPS3	Q9UNS2	PHYH	Homo sapiens	O14832	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	PHYH	Homo sapiens	O14832	Anti Bait CoIP	17353931
Intra	COPS3	Q9UNS2	GARS1	Homo sapiens	P41250	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	GARS1	Homo sapiens	P41250	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	GARS1	Homo sapiens	P41250	Y2H Array	32814053
Intra	COPS3	Q9UNS2	SNCB	Homo sapiens	Q16143	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	SNCB	Homo sapiens	Q16143	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	SNCB	Homo sapiens	Q16143	Y2H Array	32814053
Intra	COPS3	Q9UNS2	ASPA	Homo sapiens	P45381	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	ASPA	Homo sapiens	P45381	Y2H Array	32814053
Intra	COPS3	Q9UNS2	ASPA	Homo sapiens	P45381	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	COPS3	Q9UNS2	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	DBH	Homo sapiens	P09172	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	DBH	Homo sapiens	P09172	Y2H Array	32814053
Intra	COPS3	Q9UNS2	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	COPS3	Q9UNS2	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	COPS3	Q9UNS2	PEX1	Homo sapiens	O43933	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

COPS3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82446	COPS3 Antibody (YA2191)	WB, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Bone Angioendothelial Sarcoma

Osseous Hemangiosarcoma

Bone Angiosarcoma

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Parosteal Osteosarcoma

Juxtacortical Osteosarcoma	Parosteal Osteogenic Sarcoma
Osteosarcoma, Juxtacortical

Peripheral Osteosarcoma

Surface Osteosarcoma

Bone Surface Osteosarcoma

Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma

Conventional Osteosarcoma

Intracortical Osteosarcoma	Conventional Central Osteosarcoma
Intracortical Osteogenic Sarcoma	Medullary Osteosarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Potocki-Lupski Syndrome

PTLS	Chromosome 17p11.2 Duplication Syndrome
17p11.2 Microduplication Syndrome	Duplication 17p11.2 Syndrome
Trisomy 17p11.2	Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))
17p11.2 Duplication Syndrome	Dup(17)(P11.2p11.2)
Pls	Chromosome 17, Trisomy 17p11 2

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03028	COPS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	COPS3	VGNC	VGNC:61088
Rattus norvegicus	COPS3	RGD	RGD:1303002
Macaca mulatta	COPS3	VGNC	VGNC:71316
Mus musculus	COPS3	MGD	MGI:1349409
Canis familiaris	COPS3	VGNC	VGNC:39510
Bos taurus	COPS3	VGNC	VGNC:27600

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