2. Gene
  3. LPXN - leupaxin Gene

LPXN - leupaxin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LDPL

Gene ID: 9404 | Gene type: protein coding

About LPXN

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:58,526,871-58,578,891 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 15.3), appendix (RPKM 9.9) and 22 other tissues.

Summary

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with Pyk2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

LPXN Products(3)

mRNA Protein Name
NM_001143995.3 NP_001137467.1 leupaxin isoform 1
NM_001307951.2 NP_001294880.1 leupaxin isoform 3
NM_004811.3 NP_004802.1 leupaxin isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17640867 GOA
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
18451096 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
17640867 GOA
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
20543562 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17640867 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
18451096 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18451096 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17640867 GOA
located in podosome IDA
IDA: Inferred from direct assay
12674328 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPXN Protein Structure

LIM

LIM: LIM domain (152 - 207)

LIM

LIM: LIM domain (211 - 265)

LIM

LIM: LIM domain (270 - 324)

LIM

LIM: LIM domain (329 - 383)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

leupaxin

LPXN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra LPXN O60711 RUNX1T1 Homo sapiens Q06455-4
Validated Y2H
25416956
Intra LPXN O60711 RUNX1T1 Homo sapiens Q06455-4
Y2H Prey Pooling
25416956
Intra LPXN O60711 PLEKHN1 Homo sapiens Q494U1
Y2H Array
25416956
Intra LPXN O60711 PLEKHN1 Homo sapiens Q494U1
Y2H Prey Pooling
25416956
Intra LPXN O60711 VCL Homo sapiens P18206-2
Validated Y2H
32296183
Intra LPXN O60711 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra LPXN O60711 POM121 Homo sapiens Q96HA1-2
Validated Y2H
32296183
Intra LPXN O60711 RUNX1T1 Homo sapiens Q06455-2
Validated Y2H
32296183
Intra LPXN O60711 PLEKHN1 Homo sapiens Q494U1-3
Validated Y2H
32296183
Intra LPXN O60711 HOXC9 Homo sapiens P31274
Y2H Array
31515488
Intra LPXN O60711 HOXC9 Homo sapiens P31274
Validated Y2H
25416956
Intra LPXN O60711 HOXC9 Homo sapiens P31274
Validated Y2H
32296183
Intra LPXN O60711 HOXC9 Homo sapiens P31274
Y2H Array
25416956
Intra LPXN O60711 HOXC9 Homo sapiens P31274
Y2H Prey Pooling
25416956
Intra LPXN O60711 PLEKHH2 Homo sapiens Q8IVE3
Anti Tag CoIP
33961781
Intra LPXN O60711 PLEKHH2 Homo sapiens Q8IVE3
Validated Y2H
25416956
Intra LPXN O60711 PLEKHH2 Homo sapiens Q8IVE3
Anti Tag CoIP
28514442
Intra LPXN O60711 PLEKHH2 Homo sapiens Q8IVE3
Y2H Array
25416956
Cross LPXN O60711 Hoxa1 Mus musculus P09022
Y2H
23088713
Intra LPXN O60711 TXLNB Homo sapiens Q8N3L3
Y2H Array
25416956
Intra LPXN O60711 PTK2 Homo sapiens Q05397
Anti Tag CoIP
28514442
Intra LPXN O60711 PTK2 Homo sapiens Q05397
Anti Tag CoIP
33961781
Intra LPXN O60711 PTK2 Homo sapiens Q05397
Y2H
21900206
Intra LPXN O60711 AGXT Homo sapiens P21549
Validated Y2H
32296183
Intra LPXN O60711 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra LPXN O60711 TGFB1 Homo sapiens P01137
Validated Y2H
32296183
Intra LPXN O60711 LMO1 Homo sapiens P25800
Validated Y2H
32296183
Intra LPXN O60711 TNS2 Homo sapiens Q63HR2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cholelithiasis
Lipid Metabolism Disorder

Dyslipidemia

Disorder Of Fatty Acid Metabolism

Lipid Metabolism Disorders

Fatty Acid Metabolism Disorder

Disorder Of Lipid Metabolism

Abnormality Of Lipid Metabolism

Lipid Metabolism, Inborn Errors

Dyslipidemias

Disorders Of Lipid Metabolism

Congenital Disorders Of Lipid Metabolism

Inherited Disorders Of Lipid Metabolism
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diabetes Mellitus

Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07775 LPXN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LPXN VGNC VGNC:42756
Rattus norvegicus LPXN RGD RGD:1304981
Felis catus LPXN VGNC VGNC:63271
Macaca mulatta LPXN VGNC VGNC:74286
Mus musculus LPXN MGD MGI:2147677
Bos taurus LPXN VGNC VGNC:30971