2. Gene
  3. HOXC9 - homeobox C9 Gene

HOXC9 - homeobox C9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HOX3; HOX3B

Gene ID: 3225 | Gene type: protein coding

About HOXC9

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,000,161-54,003,337 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 42 paralogues. Biased expression in kidney (RPKM 2.8), fat (RPKM 2.6) and 10 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]

HOXC9 Products(1)

mRNA Protein Name
NM_006897.3 NP_008828.1 homeobox protein Hox-C9
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18305892 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Cellular Component GO Annotation Evidence Reference Source
part of transcription repressor complex IPI
IPI: Inferred from physical interaction
22615398 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXC9 Protein Structure

Hox9_act

Hox9_act: Hox9 activation region (1 - 179)

Homeobox

Homeobox: Homeobox domain (193 - 249)

  • 0
  • 100
  • 200
  • 260 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-C9

homeo box C9

HOXC9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HOXC9 P31274 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra
HOXC9 P31274 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra
HOXC9 P31274 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
HOXC9 P31274 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
HOXC9 P31274 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
HOXC9 P31274 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
HOXC9 P31274 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
HOXC9 P31274 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
HOXC9 P31274 UFSP1 Homo sapiens Q6NVU6
Y2H Array
32296183
Intra
HOXC9 P31274 UFSP1 Homo sapiens Q6NVU6
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 UFSP1 Homo sapiens Q6NVU6
Validated Y2H
32296183
Cross
HOXC9 P31274 E2 Human papillomavirus P03120
Y2H
18305892
Cross
HOXC9 P31274 E2 Human papillomavirus P03120
SLC
22761572
Intra
HOXC9 P31274 PAX8 Homo sapiens Q06710
Validated Y2H
32296183
Intra
HOXC9 P31274 PAX8 Homo sapiens Q06710
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 PAX8 Homo sapiens Q06710
Y2H Array
32296183
Intra
HOXC9 P31274 PBX2 Homo sapiens P40425
Validated Y2H
32296183
Intra
HOXC9 P31274 PBX2 Homo sapiens P40425
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 PBX2 Homo sapiens P40425
Y2H Array
32296183
Intra
HOXC9 P31274 GMNN Homo sapiens O75496
Pull Down
22615398
Intra
HOXC9 P31274 GMNN Homo sapiens O75496
NMR
22615398
Intra
HOXC9 P31274 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
HOXC9 P31274 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 MSX2 Homo sapiens P35548
Validated Y2H
32296183
Intra
HOXC9 P31274 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra
HOXC9 P31274 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
HOXC9 P31274 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
HOXC9 P31274 SPMIP9 Homo sapiens Q96LM6
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 SPMIP9 Homo sapiens Q96LM6
Validated Y2H
32296183
Intra
HOXC9 P31274 SPMIP9 Homo sapiens Q96LM6
Y2H Array
32296183
Intra
HOXC9 P31274 LPXN Homo sapiens O60711
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 LPXN Homo sapiens O60711
Y2H Array
32296183
Intra
HOXC9 P31274 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
HOXC9 P31274 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
HOXC9 P31274 POU2AF1 Homo sapiens Q16633
Y2H Array
32296183
Intra
HOXC9 P31274 POU2AF1 Homo sapiens Q16633
Validated Y2H
32296183
Intra
HOXC9 P31274 POU2AF1 Homo sapiens Q16633
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06321 HOXC9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HOXC9 VGNC VGNC:67630
Rattus norvegicus HOXC9 RGD RGD:1595784
Bos taurus HOXC9 VGNC VGNC:29928
Mus musculus HOXC9 MGD MGI:96199