TBPL1 - TATA-box binding protein like 1 Gene

Homo sapiens

Also known as TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620

Gene ID: 9519 | Gene type: protein coding

About TBPL1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:133,952,174-133,990,432 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and 2 paralogues. Broad expression in testis (RPKM 58.3), bone marrow (RPKM 8.1) and 20 other tissues.

Summary

This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]

TBPL1 Products(2)

mRNA	Protein	Name
NM_001253676.2	NP_001240605.1	TATA box-binding protein-like 1
NM_004865.4	NP_004856.1	TATA box-binding protein-like 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15767669	GOA
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	10220372	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24835508	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBPL1 Protein Structure

TBP

0
100
186 a.a.

Protein Preferred Names

Protein Names

TATA box-binding protein-like 1

21-kDA TBP-like protein

TBPL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TBPL1	P62380	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	32296183
Intra	TBPL1	P62380	GTF2A1	Homo sapiens	P52655	Anti Bait CoIP	17353931
Intra	TBPL1	P62380	GTF2A1	Homo sapiens	P52655	Anti Bait CoIP	24835508
Intra	TBPL1	P62380	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	TBPL1	P62380	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	TBPL1	P62380	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	TBPL1	P62380	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	TBPL1	P62380	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	TBPL1	P62380	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	TBPL1	P62380	TNNT1	Homo sapiens	P13805	Y2H Array	25416956
Intra	TBPL1	P62380	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	TBPL1	P62380	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	TBPL1	P62380	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Kummell'S Disease

Traumatic Spondylopathy	Kummell Disease
Kummell'S Spondylitis	Kümmelll-Verneuil Disease
Kümmell Spondylitis	Kümmell Disease
Traumatic Spondylosis

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Infertility

Myofascial Pain Syndrome

Myofascial Pain Syndromes	Myofascial Pain Dysfunction Syndrome
Fibromyalgia

Spondylolisthesis

Slipped Vertebrae

Acquired Spondylolisthesis

Trypanosomiasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14267	TBPL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TBPL1	MGD	MGI:1339946
Bos taurus	TBPL1	VGNC	VGNC:35660
Felis catus	TBPL1	VGNC	VGNC:102532
Macaca mulatta	TBPL1	VGNC	VGNC:83491
Rattus norvegicus	TBPL1	RGD	RGD:1597456

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