DCAF1 - DDB1 and CUL4 associated factor 1 Gene

Homo sapiens

Also known as RIP; VPRBP

Gene ID: 9730 | Gene type: protein coding

About DCAF1

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,395,867-51,505,639 (from NCBI)

This gene has 4 transcripts (splice variants) and 254 orthologues. Broad expression in testis (RPKM 27.5), thyroid (RPKM 8.3) and 24 other tissues.

Summary

Enables Estrogen Receptor binding activity and histone kinase activity (H2A-T120 specific). Involved in cell competition in a multicellular organism; histone H2A-T120 phosphorylation; and negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of Cul4-RING E3 ubiquitin Ligase complex. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

DCAF1 Products(12)

mRNA	Protein	Name
NM_001171904.2	NP_001165375.1	DDB1- and CUL4-associated factor 1 isoform 2
NM_001349168.2	NP_001336097.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001349169.2	NP_001336098.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001349170.2	NP_001336099.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001349171.2	NP_001336100.1	DDB1- and CUL4-associated factor 1 isoform 3
NM_001387578.1	NP_001374507.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001387579.1	NP_001374508.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001387580.1	NP_001374509.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001387581.1	NP_001374510.1	DDB1- and CUL4-associated factor 1 isoform 1
NM_001387582.1	NP_001374511.1	DDB1- and CUL4-associated factor 1 isoform 2
NM_001387583.1	NP_001374512.1	DDB1- and CUL4-associated factor 1 isoform 3
NM_014703.3	NP_055518.1	DDB1- and CUL4-associated factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H2AT120 kinase activity	IDA IDA: Inferred from direct assay	24140421	GOA
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	28068668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16949367	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	23063525	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell competition in a multicellular organism	IMP IMP: Inferred from mutant phenotype	20644714	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24140421	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	23063525	GOA
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	24140421	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	28242748	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16949367	GOA
is active in centrosome	IDA IDA: Inferred from direct assay	28242748	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20178741	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DDB1- and CUL4-associated factor 1

HIV-1 Vpr-binding protein

Related Diseases

Diseases

Alias

Intraorbital Meningioma

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Acoustic Neuroma

Neurofibromatosis Type 2	Vestibular Schwannoma
Acoustic Neurinoma	Bilateral Acoustic Neurofibromatosis
Nf2	Acoustic Neurilemoma
Cerebellopontine Angle Tumor	Neurofibromatosis Central Type
Neurofibromatosis Type Ii	Vestibular Neurilemmoma
Acoustic Tumor	Neurinoma Of The Acoustic Nerve
Acoustic Neurinoma Bilateral	Acoustic Schwannomas Bilateral
Banf	Central Neurofibromatosis
Familial Acoustic Neuromas	Neurofibromatosis 2
Neurofibromatosis Type 2 Merlin	Schwannoma, Acoustic, Bilateral
Neuroma Acoustic	Neuroma, Acoustic
Familial Acoustic Neuroma	Familial Vestibular Schwannoma
Neurofibromatosis, Central Type	Nf2 - [Neurofibromatosis Type 2]

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Neurilemmoma

Schwannoma	Benign Schwannoma
Neurilemoma	Peripheral Fibroblastoma
Psammomatous Schwannoma	Neurolemmoma
Schwannomas

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149934	DCAF1 binder 1		99.12%	Unkown
HY-149307	CYCA-117-70		/	Unkown
HY-149935	OICR-8268		/	Unkown
HY-160876	BC-1901S	Activator	/	Unkown
HY-169147	MY-11B		/	Unkown
HY-169151	PROTAC BRD4-DCAF1 degrader-1		/	Unkown
HY-169152	DCAF1 ligand 1		/	Unkown
HY-RS03557	DCAF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-156743	DCAF1 binder 2		/	Unkown
HY-159777	CPI-203-PEG5-Alkyne		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DCAF1	VGNC	VGNC:71819
Canis familiaris	DCAF1	VGNC	VGNC:39788
Felis catus	DCAF1	VGNC	VGNC:61353
Mus musculus	DCAF1	MGD	MGI:2445220
Bos taurus	DCAF1	VGNC	VGNC:27899
Rattus norvegicus	DCAF1	RGD	RGD:1305176
Others	DCAF1	NCBI

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