1. Gene
  2. DCAF1 - DDB1 and CUL4 associated factor 1 Gene

DCAF1 - DDB1 and CUL4 associated factor 1 Gene

Homo sapiens

Also known as RIP; VPRBP

Gene ID: 9730 | Gene type: protein coding

About DCAF1

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,395,867-51,505,639 (from NCBI)

This gene has 4 transcripts (splice variants) and 254 orthologues. Broad expression in testis (RPKM 27.5), thyroid (RPKM 8.3) and 24 other tissues.

Summary

Enables Estrogen Receptor binding activity and histone kinase activity (H2A-T120 specific). Involved in cell competition in a multicellular organism; histone H2A-T120 phosphorylation; and negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of Cul4-RING E3 ubiquitin Ligase complex. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

DCAF1 Products(12)

mRNA Protein Name
NM_001171904.2 NP_001165375.1 DDB1- and CUL4-associated factor 1 isoform 2
NM_001349168.2 NP_001336097.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001349169.2 NP_001336098.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001349170.2 NP_001336099.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001349171.2 NP_001336100.1 DDB1- and CUL4-associated factor 1 isoform 3
NM_001387578.1 NP_001374507.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001387579.1 NP_001374508.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001387580.1 NP_001374509.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001387581.1 NP_001374510.1 DDB1- and CUL4-associated factor 1 isoform 1
NM_001387582.1 NP_001374511.1 DDB1- and CUL4-associated factor 1 isoform 2
NM_001387583.1 NP_001374512.1 DDB1- and CUL4-associated factor 1 isoform 3
NM_014703.3 NP_055518.1 DDB1- and CUL4-associated factor 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone H2AT120 kinase activity IDA
IDA: Inferred from direct assay
24140421 GOA
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
28068668 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16949367 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
23063525 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell competition in a multicellular organism IMP
IMP: Inferred from mutant phenotype
20644714 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24140421 GOA
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
23063525 GOA
involved in post-translational protein modification IDA
IDA: Inferred from direct assay
24140421 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
28242748 GOA
Cellular Component GO Annotation Evidence Reference Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16949367 GOA
is active in centrosome IDA
IDA: Inferred from direct assay
28242748 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20178741 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DDB1- and CUL4-associated factor 1

HIV-1 Vpr-binding protein

DCAF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DCAF1 Q9Y4B6 DDB1 Homo sapiens Q16531
Density Sedimentation
24412650
Intra
DCAF1 Q9Y4B6 LATS2 Homo sapiens Q9NRM7
Anti Tag CoIP
25026211
Intra
DCAF1 Q9Y4B6 LATS2 Homo sapiens Q9NRM7
Ubiquitinase Assay
25026211
Intra
DCAF1 Q9Y4B6 LATS1 Homo sapiens O95835
Anti Tag CoIP
25026211
Intra
DCAF1 Q9Y4B6 LATS1 Homo sapiens O95835
Pull Down
25026211
Intra
DCAF1 Q9Y4B6 LATS1 Homo sapiens O95835
Ubiquitinase Assay
25026211
Cross
DCAF1 Q9Y4B6 a0a0h3lac5_mycte Mycobacterium tuberculosis A0A0H3LAC5
Anti Bait CoIP
30118682
Cross
DCAF1 Q9Y4B6 vpr Human immunodeficiency virus P12520
Pull Down
22190034
Cross
DCAF1 Q9Y4B6 vpx Human immunodeficiency virus P18045
Anti Tag CoIP
19264781
Cross
DCAF1 Q9Y4B6 vpx Simian immunodeficiency virus P19508
GMS
24336198
Cross
DCAF1 Q9Y4B6 vpx Simian immunodeficiency virus P19508
X-Ray Diffraction
24336198
Cross
DCAF1 Q9Y4B6 vpx Simian immunodeficiency virus P19508
Anti Tag CoIP
19264781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intraorbital Meningioma
Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Acoustic Neuroma

Neurofibromatosis Type 2

Vestibular Schwannoma

Acoustic Neurinoma

Bilateral Acoustic Neurofibromatosis

Nf2

Acoustic Neurilemoma

Cerebellopontine Angle Tumor

Neurofibromatosis Central Type

Neurofibromatosis Type Ii

Vestibular Neurilemmoma

Acoustic Tumor

Neurinoma Of The Acoustic Nerve

Acoustic Neurinoma Bilateral

Acoustic Schwannomas Bilateral

Banf

Central Neurofibromatosis

Familial Acoustic Neuromas

Neurofibromatosis 2

Neurofibromatosis Type 2 Merlin

Schwannoma, Acoustic, Bilateral

Neuroma Acoustic

Neuroma, Acoustic

Familial Acoustic Neuroma

Familial Vestibular Schwannoma

Neurofibromatosis, Central Type

Nf2 - [Neurofibromatosis Type 2]

Neurofibromatosis, Type Ii

Neurofibromatosis 2

Neurofibromatosis, Type 2

NF2

Neurofibromatosis Type Ii

Bilateral Acoustic Neurofibromatosis

Banf

Acn

Central Neurofibromatosis

Neurofibromatosis, Central Type

Acoustic Schwannomas, Bilateral

Acoustic Neurinoma, Bilateral

Bilateral Acoustic Neurinoma

Bilateral Acoustic Schwannomas

Familial Acoustic Neuromas

Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Neurilemmoma

Schwannoma

Benign Schwannoma

Neurilemoma

Peripheral Fibroblastoma

Psammomatous Schwannoma

Neurolemmoma

Schwannomas

Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta DCAF1 VGNC VGNC:71819
Canis familiaris DCAF1 VGNC VGNC:39788
Felis catus DCAF1 VGNC VGNC:61353
Mus musculus DCAF1 MGD MGI:2445220
Bos taurus DCAF1 VGNC VGNC:27899
Rattus norvegicus DCAF1 RGD RGD:1305176
Others DCAF1 NCBI