ZFYVE16 - zinc finger FYVE-type containing 16 Gene

Homo sapiens

Also known as PPP1R69

Gene ID: 9765 | Gene type: protein coding

About ZFYVE16

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:80,407,610-80,483,379 (from NCBI)

This gene has 13 transcripts (splice variants), 95 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 10.1), endometrium (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ZFYVE16 Products(5)

mRNA	Protein	Name
NM_001105251.4	NP_001098721.2	zinc finger FYVE domain-containing protein 16 isoform a
NM_001284236.3	NP_001271165.2	zinc finger FYVE domain-containing protein 16 isoform a
NM_001284237.2	NP_001271166.2	zinc finger FYVE domain-containing protein 16 isoform b
NM_001349434.2	NP_001336363.2	zinc finger FYVE domain-containing protein 16 isoform a
NM_014733.6	NP_055548.4	zinc finger FYVE domain-containing protein 16 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol binding	IDA IDA: Inferred from direct assay	11546807	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	11433298	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14613930	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	11546807	GOA
involved in protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	11546807	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	11546807	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE16 Protein Structure

FYVE

DUF3480

0
300
600
900
1200
1539 a.a.

Protein Preferred Names

Protein Names

zinc finger FYVE domain-containing protein 16

endosome-associated FYVE-domain protein

ZFYVE16 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFYVE16	Q7Z3T8	EEA1	Homo sapiens	Q15075	Density Sedimentation	14613930
Intra	ZFYVE16	Q7Z3T8	PPP1CA	Homo sapiens	P62136	Y2H	15231748
Intra	ZFYVE16	Q7Z3T8	TOM1	Homo sapiens	O60784	Pull Down	14613930

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Gluten Allergy

Allergy To Gluten

Gluten Allergic Reaction

Psoriasis 14, Pustular

Generalized Pustular Psoriasis	Gpp
Ditra	Acrodermatitis Continua Of Hallopeau
Palmoplantar Pustulosis	PSORS14
Interleukin 36 Receptor Antagonist Deficiency	Psorp
Pustular Psoriasis 14	Deficiency Of Il-36r Antagonist
Acute Generalised Pustular Psoriasis	Deficiency Of The Interleukin-36 Receptor Antagonist
Generalized Pustular Psoriasis Of Von Zumbusch	Von Zumbusch Psoriasis
Deficiency Of Il-36ra	Psoriasis, Pustular, Generalized
Psoriasis, Pustular, Type 14	Pustulosis Of Palms And Soles
Acute Generalized Pustular Psoriasis	Palmoplantar Pustular Psoriasis
Pustulosis Palmaris Et Plantaris	Ppp - [Palmoplantar Pustulosis]
Pustular Psoriasis Of The Palms And Soles	Pustular Bacterid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16056	ZFYVE16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZFYVE16	VGNC	VGNC:79281
Mus musculus	ZFYVE16	MGD	MGI:2145181
Canis familiaris	ZFYVE16	VGNC	VGNC:48623
Bos taurus	ZFYVE16	VGNC	VGNC:37174
Rattus norvegicus	ZFYVE16	RGD	RGD:1564784
Felis catus	ZFYVE16	VGNC	VGNC:67238

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