1. Gene
  2. ACYP2 - acylphosphatase 2 Gene

ACYP2 - acylphosphatase 2 Gene

Homo sapiens

Also known as ACYM; ACYP

Gene ID: 98 | Gene type: protein coding

About ACYP2

Cytogenetic location: 2p16.2 Genomic coordinates (GRCh38): 2:53,971,113-54,305,300 (from NCBI)

This gene has 9 transcripts (splice variants), 238 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 3.1), heart (RPKM 2.8) and 25 other tissues.

Summary

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ACYP2 Products(6)

mRNA Protein Name
NM_001320586.2 NP_001307515.1 acylphosphatase-2 isoform 1
NM_001320587.2 NP_001307516.1 acylphosphatase-2 isoform 2
NM_001320588.2 NP_001307517.1 acylphosphatase-2 isoform 4
NM_001320589.2 NP_001307518.1 acylphosphatase-2 isoform 5
NM_001320590.2 NP_001307519.1 acylphosphatase-2 isoform 6
NM_138448.4 NP_612457.1 acylphosphatase-2 isoform 3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12374855 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACYP2 Protein Structure

Acylphosphatase

Acylphosphatase: Acylphosphatase (8 - 98)

  • 0
  • 99 a.a.
Protein Preferred Names Protein Names

acylphosphatase-2

acylphosphatase 2, muscle type

ACYP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ACYP2 P14621 GFPT2 Homo sapiens O94808 33961781
Intra
ACYP2 P14621 ACYP2 Homo sapiens P14621 12374855
Intra
ACYP2 P14621 SULT2B1 Homo sapiens O00204 25416956
Intra
ACYP2 P14621 ACYP2 Homo sapiens P14621 16084386
Intra
ACYP2 P14621 ACYP2 Homo sapiens P14621
DLS
16084386
Intra
ACYP2 P14621 CARM1 Homo sapiens Q86X55 33961781
Intra
ACYP2 P14621 OGA Homo sapiens O60502 33961781
Intra
ACYP2 P14621 BCS1L Homo sapiens Q9Y276 33961781
Intra
ACYP2 P14621 SULT2B1 Homo sapiens O00204 25416956
Intra
ACYP2 P14621 CREBZF Homo sapiens Q9NS37 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACYP2 Proteins

Cat. No. Product Name Accession Purity
HY-P7459 Acylphosphatase-2/ACYP2 Protein, Human (GST) P14621 (S2-Y99) ≥95%

Orthologs Information

Species Symbol Source ID
Felis catus ACYP2 VGNC VGNC:98504
Mus musculus ACYP2 MGD MGI:1922822
Rattus norvegicus ACYP2 RGD RGD:1595836
Canis familiaris ACYP2 VGNC VGNC:37567
Macaca mulatta ACYP2 VGNC VGNC:82096
Bos taurus ACYP2 VGNC VGNC:25599
Others ACYP2 NCBI