NUAK1 - NUAK family kinase 1 Gene

Homo sapiens

Also known as ARK5

Gene ID: 9891 | Gene type: protein coding

About NUAK1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,063,345-106,138,954 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 17 paralogues. Broad expression in brain (RPKM 19.6), skin (RPKM 9.2) and 19 other tissues.

Summary

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

NUAK1 Products(1)

mRNA	Protein	Name
NM_014840.3	NP_055655.1	NUAK family SNF1-like kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables p53 binding	IPI IPI: Inferred from physical interaction	21317932	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16306228	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19927127	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	25329316	GOA
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	20354225	GOA
involved in regulation of cellular senescence	IDA IDA: Inferred from direct assay	19927127	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21317932	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21317932	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUAK1 Protein Structure

Pkinase

0
200
400
600
661 a.a.

Protein Preferred Names

Protein Names

NUAK family SNF1-like kinase 1

AMP-activated protein kinase family member 5	AMPK-related protein kinase 5
NUAK family, SNF1-like kinase, 1	omphalocele kinase 1

NUAK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUAK1	O60285	SRRM2	Homo sapiens	Q9UQ35	Anti Tag CoIP	25852190
Intra	NUAK1	O60285	SRRM2	Homo sapiens	Q9UQ35	Pull Down	32707033
Intra	NUAK1	O60285	USP9X	Homo sapiens	Q93008	TAP	16306228
Intra	NUAK1	O60285	USP9X	Homo sapiens	Q93008	Pull Down	32707033
Intra	NUAK1	O60285	TP53	Homo sapiens	P04637	Protein Kinase Assay	21317932
Intra	NUAK1	O60285	TP53	Homo sapiens	P04637	CH-IP	21317932

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Omphalocele

Omphalocoele	Congenital Omphalocele
Exomphalos	Exumbilication

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Endometrial Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Endometrium

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12624	Narazaciclib	Inhibitor	99.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12334	HTH-01-015	Inhibitor	98.81%	Unkown
HY-15802	WZ4003	Inhibitor	98.03%	Unkown
HY-120877	MRT199665	Inhibitor	99.74%	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NUAK1	VGNC	VGNC:75403
Rattus norvegicus	NUAK1	RGD	RGD:1309956
Bos taurus	NUAK1	VGNC	VGNC:50006
Mus musculus	NUAK1	MGD	MGI:1925226
Canis familiaris	NUAK1	VGNC	VGNC:54977
Others	NUAK1	NCBI

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