Ssx2ip - synovial sarcoma, X 2 interacting protein Gene

Mus musculus

Also known as Adip

Gene ID: 99167 | Gene type: protein coding

About Ssx2ip

Summary

Predicted to enable protein domain specific binding activity. Acts upstream of or within regulation of Rac protein signal transduction and regulation of cell motility. Located in cell leading edge; centriolar satellite; and ciliary basal body. Orthologous to human SSX2IP (SSX family member 2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Ssx2ip Products(19)

mRNA	Protein	Name
NM_001253768.2	NP_001240697.1	afadin- and alpha-actinin-binding protein isoform b
NM_001253769.2	NP_001240698.1	afadin- and alpha-actinin-binding protein isoform b
NM_001253770.2	NP_001240699.1	afadin- and alpha-actinin-binding protein isoform b
NM_001355661.1	NP_001342590.1	afadin- and alpha-actinin-binding protein isoform a
NM_001411104.1	NP_001398033.1	afadin- and alpha-actinin-binding protein isoform a
NM_001411105.1	NP_001398034.1	afadin- and alpha-actinin-binding protein isoform a
NM_001411107.1	NP_001398036.1	afadin- and alpha-actinin-binding protein isoform a
NM_001411108.1	NP_001398037.1	afadin- and alpha-actinin-binding protein isoform a
NM_001411109.1	NP_001398038.1	afadin- and alpha-actinin-binding protein isoform a
NM_001411110.1	NP_001398039.1	afadin- and alpha-actinin-binding protein isoform b
NM_001411114.1	NP_001398043.1	afadin- and alpha-actinin-binding protein isoform b
NM_001411115.1	NP_001398044.1	afadin- and alpha-actinin-binding protein isoform b
NM_001411116.1	NP_001398045.1	afadin- and alpha-actinin-binding protein isoform c
NM_001411117.1	NP_001398046.1	afadin- and alpha-actinin-binding protein isoform c
NM_001411118.1	NP_001398047.1	afadin- and alpha-actinin-binding protein isoform c
NM_001411119.1	NP_001398048.1	afadin- and alpha-actinin-binding protein isoform d
NM_001411120.1	NP_001398049.1	afadin- and alpha-actinin-binding protein isoform d
NM_001411121.1	NP_001398050.1	afadin- and alpha-actinin-binding protein isoform e
NM_138744.4	NP_620083.1	afadin- and alpha-actinin-binding protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12446711	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	22027834	MGI
acts upstream of or within regulation of cell motility	IMP IMP: Inferred from mutant phenotype	22027834	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	22027834	MGI
located in centriolar satellite	IDA IDA: Inferred from direct assay	24356449	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	24356449	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

afadin- and alpha-actinin-binding protein

afadin DIL domain-interacting protein

synovial sarcoma, X breakpoint 2 interacting protein

Ssx2ip Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ssx2ip	Q8VC66	ACTN1	Homo sapiens	P12814	Anti Tag CoIP	12446711
Cross	Ssx2ip	Q8VC66	Afdn	Rattus norvegicus	O35889	Anti Tag CoIP	12446711
Cross	Ssx2ip	Q8VC66	Afdn	Rattus norvegicus	O35889	Y2H	12446711
Cross	Ssx2ip	Q8VC66	Afdn	Rattus norvegicus	O35889	Pull Down	12446711

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13838	SSX2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ssx2ip	NCBI	NCBI:117178

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