RNF10 - ring finger protein 10 Gene

Homo sapiens

Also known as RIE2

Gene ID: 9921 | Gene type: protein coding

About RNF10

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,534,356-120,577,588 (from NCBI)

This gene has 25 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 52.4), bone marrow (RPKM 51.8) and 25 other tissues.

Summary

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

RNF10 Products(2)

mRNA	Protein	Name
NM_001330474.2	NP_001317403.1	RING finger protein 10 isoform 2
NM_014868.5	NP_055683.3	RING finger protein 10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16335786	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	24105792	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16335786	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	24105792	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	34348161	GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	34348161	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16335786	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	34348161	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF10 Protein Structure

zf-C3HC4_2

0
200
400
600
811 a.a.

Protein Preferred Names

Protein Names

RING finger protein 10

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Superficial Keratitis

Leukodystrophy, Hypomyelinating, 2

Pmld1	Hypomyelinating Leukodystrophy 2
HLD2	Pelizaeus-Merzbacher-Like Disease 1
Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation	Pelizaeus-Merzbacher-Like Disease Type 1
Pelizaeus-Merzbacher-Like Disease, 1	Pelizaeus Merzbacher Like Disease
Pelizaeus-Merzbacher-Like Disease	Pmld - Pelizaeus Merzbacher Like Disease
Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1	Pmldar1
Leukodystrophy, Hypomyelinating, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12034	RNF10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF10	MGD	MGI:1859162
Canis familiaris	RNF10	VGNC	VGNC:97218
Bos taurus	RNF10	VGNC	VGNC:34007
Rattus norvegicus	RNF10	RGD	RGD:1309282
Macaca mulatta	RNF10	VGNC	VGNC:76702
Others	RNF10	NCBI

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