1. Gene
  2. JOSD1 - Josephin domain containing 1 Gene

JOSD1 - Josephin domain containing 1 Gene

Homo sapiens

Also known as dJ508I15.2

Gene ID: 9929 | Gene type: protein coding

About JOSD1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,685,543-38,701,403 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 27.2), gall bladder (RPKM 19.0) and 25 other tissues.

Summary

Predicted to enable thiol-dependent Deubiquitinase. Predicted to be involved in protein deubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

JOSD1 Products(3)

mRNA Protein Name
NM_001360235.2 NP_001347164.1 josephin-1
NM_001360236.2 NP_001347165.1 josephin-1
NM_014876.7 NP_055691.1 josephin-1

JOSD1 Protein Structure

Josephin

Josephin: Josephin (30 - 177)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

josephin-1

josephin domain-containing 1

JOSD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
JOSD1 Q15040 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra
JOSD1 Q15040 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
JOSD1 Q15040 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
JOSD1 Q15040 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
JOSD1 Q15040 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25416956
Intra
JOSD1 Q15040 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
JOSD1 Q15040 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
JOSD1 Q15040 KRTAP10-4 Homo sapiens P60372
Validated Y2H
25416956
Intra
JOSD1 Q15040 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
JOSD1 Q15040 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
JOSD1 Q15040 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
Intra
JOSD1 Q15040 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
JOSD1 Q15040 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra
JOSD1 Q15040 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
JOSD1 Q15040 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
JOSD1 Q15040 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
JOSD1 Q15040 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
JOSD1 Q15040 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
JOSD1 Q15040 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
JOSD1 Q15040 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
JOSD1 Q15040 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
JOSD1 Q15040 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
JOSD1 Q15040 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra
JOSD1 Q15040 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
JOSD1 Q15040 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
JOSD1 Q15040 TRAF1 Homo sapiens Q13077
Validated Y2H
25416956
Intra
JOSD1 Q15040 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra
JOSD1 Q15040 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra
JOSD1 Q15040 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
JOSD1 Q15040 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
JOSD1 Q15040 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
JOSD1 Q15040 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
JOSD1 Q15040 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
JOSD1 Q15040 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
JOSD1 Q15040 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
JOSD1 Q15040 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
JOSD1 Q15040 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
JOSD1 Q15040 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
JOSD1 Q15040 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
JOSD1 Q15040 FBLN2 Homo sapiens P98095
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 FBLN2 Homo sapiens P98095
Y2H Array
32296183
Intra
JOSD1 Q15040 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
JOSD1 Q15040 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
JOSD1 Q15040 KRT86 Homo sapiens O43790
Y2H Prey Pooling
32296183
Intra
JOSD1 Q15040 KRT86 Homo sapiens O43790
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta JOSD1 VGNC VGNC:73920
Felis catus JOSD1 VGNC VGNC:84041
Bos taurus JOSD1 VGNC VGNC:30379
Rattus norvegicus JOSD1 RGD RGD:1305388
Canis familiaris JOSD1 VGNC VGNC:42192
Mus musculus JOSD1 MGD MGI:1921408
Others JOSD1 NCBI