GGFG-PAB-Exatecan

Cat. No.: HY-153069 Purity: 99.71%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

GGFG-PAB-Exatecan consists of an ADC toxin Exatecan (HY-13631) and a linker GGFG-PAB, and can be used as a drug-linker conjugate for the synthesis of ADC molecules.

For research use only. We do not sell to patients.

GGFG-PAB-Exatecan Chemical Structure

CAS No. : 251459-32-2

Size	Price	Stock	Quantity
5 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2980	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4170	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

GGFG-PAB-Exatecan consists of an ADC toxin Exatecan (HY-13631) and a linker GGFG-PAB, and can be used as a drug-linker conjugate for the synthesis of ADC molecules^[1].

Molecular Weight

902.92

Formula

C₄₇H₄₇FN₈O₁₀

CAS No.

251459-32-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (110.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1075 mL	5.5376 mL	11.0752 mL
5 mM	0.2215 mL	1.1075 mL	2.2150 mL
10 mM	0.1108 mL	0.5538 mL	1.1075 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.71%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (260 KB) HNMR (243 KB) RP-HPLC (264 KB) LCMS (128 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang F, et al., Epsilon-poly-l-lysine-based drug conjugate, intermediate thereof, and application thereof. WO2023078464.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1075 mL	5.5376 mL	11.0752 mL	27.6879 mL
	5 mM	0.2215 mL	1.1075 mL	2.2150 mL	5.5376 mL
	10 mM	0.1108 mL	0.5538 mL	1.1075 mL	2.7688 mL
	15 mM	0.0738 mL	0.3692 mL	0.7383 mL	1.8459 mL
	20 mM	0.0554 mL	0.2769 mL	0.5538 mL	1.3844 mL
	25 mM	0.0443 mL	0.2215 mL	0.4430 mL	1.1075 mL
	30 mM	0.0369 mL	0.1846 mL	0.3692 mL	0.9229 mL
	40 mM	0.0277 mL	0.1384 mL	0.2769 mL	0.6922 mL
	50 mM	0.0222 mL	0.1108 mL	0.2215 mL	0.5538 mL
	60 mM	0.0185 mL	0.0923 mL	0.1846 mL	0.4615 mL
	80 mM	0.0138 mL	0.0692 mL	0.1384 mL	0.3461 mL
	100 mM	0.0111 mL	0.0554 mL	0.1108 mL	0.2769 mL