2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Globotriaosylsphingosine

Globotriaosylsphingosine  (Synonyms: lyso-Gb3)

Cat. No.: HY-N12408 Purity: ≥98.0%
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Globotriaosylsphingosine (lyso-Gb3) inhibits the growth of fibroblasts, as well as their differentiation into myofibroblasts, and collagen expression. Globotriaosylsphingosine can be used for Fabry disease research.

For research use only. We do not sell to patients.

Globotriaosylsphingosine Chemical Structure

Globotriaosylsphingosine Chemical Structure

CAS No. : 126550-86-5

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Globotriaosylsphingosine Related Antibodies

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Description

Globotriaosylsphingosine (lyso-Gb3) inhibits the growth of fibroblasts, as well as their differentiation into myofibroblasts, and collagen expression. Globotriaosylsphingosine can be used for Fabry disease research[1].

In Vitro

Globotriaosylsphingosine (100 nM, 500 nM; 24 h) reduces KCa3.1 mRNA expression levels and Glo1a1 and Glo3a1 protein levels[1].
Globotriaosylsphingosine (50-500 nM, 24 h) dose-dependently inhibits fibroblast growth, differentiation into myofibroblasts, and collagen synthesis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Globotriaosylsphingosine Related Antibodies
Molecular Weight

785.91

Formula

C36H67NO17
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O[C@H]([C@@H]([C@H]1O)O)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC)CO)[C@@H]1O[C@H]3O[C@@H]([C@@H]([C@@H]([C@H]3O)O)O)CO
Structure Classification
Initial Source

Human plasma
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (2.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2724 mL 6.3621 mL 12.7241 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2724 mL 6.3621 mL 12.7241 mL 31.8103 mL
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Globotriaosylsphingosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Globotriaosylsphingosine126550-86-5lyso-Gb3Calcium ChannelCa2+ channelsCa channelsFabry diseasefibroblastInhibitorinhibitorinhibit

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