2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Antibody-drug Conjugate/ADC Related
  3. Glucocorticoid Receptor ADC Cytotoxin
  4. Glucocorticoid receptor agonist-4

Glucocorticoid receptor agonist-4 

Cat. No.: HY-160179 Purity: 99.80%
Data Sheet
SDS
COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Glucocorticoid receptor agonist-4 (Compound Preparation 5) is a glucocorticoid receptor agonist that can be conjugated to TNF-α antibodies for the study of autoimmune and inflammatory diseases.

For research use only. We do not sell to patients.

Glucocorticoid receptor agonist-4 Chemical Structure

Glucocorticoid receptor agonist-4 Chemical Structure

CAS No. : 2842165-72-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 852 In-stock
Solution
10 mM * 1 mL in DMSO USD 897 In-stock
Solid
5 mg USD 660 In-stock
10 mg USD 1050 In-stock
25 mg USD 1940 In-stock
50 mg USD 2920 In-stock
100 mg USD 4370 In-stock
200 mg   Get quote  
500 mg   Get quote  

Get it by April 30 for select sizes. Order within 19 hrs 45 mins.

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Glucocorticoid receptor agonist-4:

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Glucocorticoid receptor agonist-4 (Compound Preparation 5) is a glucocorticoid receptor agonist that can be conjugated to TNF-α antibodies for the study of autoimmune and inflammatory diseases[1].

Molecular Weight

617.70

Formula

C36H40FNO7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@@]5(C(CC4)=CC(C=C5)=O)C)([H])[C@H](C3)O)([H])C[C@@]1([H])O[C@@H](C6=C(C(OCC7=CC(N)=CC=C7)=CC=C6C)F)O2)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (323.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6189 mL 8.0945 mL 16.1891 mL
5 mM 0.3238 mL 1.6189 mL 3.2378 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (8.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6189 mL 8.0945 mL 16.1891 mL 40.4727 mL
5 mM 0.3238 mL 1.6189 mL 3.2378 mL 8.0945 mL
10 mM 0.1619 mL 0.8095 mL 1.6189 mL 4.0473 mL
15 mM 0.1079 mL 0.5396 mL 1.0793 mL 2.6982 mL
20 mM 0.0809 mL 0.4047 mL 0.8095 mL 2.0236 mL
25 mM 0.0648 mL 0.3238 mL 0.6476 mL 1.6189 mL
30 mM 0.0540 mL 0.2698 mL 0.5396 mL 1.3491 mL
40 mM 0.0405 mL 0.2024 mL 0.4047 mL 1.0118 mL
50 mM 0.0324 mL 0.1619 mL 0.3238 mL 0.8095 mL
60 mM 0.0270 mL 0.1349 mL 0.2698 mL 0.6745 mL
80 mM 0.0202 mL 0.1012 mL 0.2024 mL 0.5059 mL
100 mM 0.0162 mL 0.0809 mL 0.1619 mL 0.4047 mL
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Glucocorticoid receptor agonist-4 Related Classifications

Keywords:

Glucocorticoid receptor agonist-42842165-72-2Glucocorticoid receptor agonist4Glucocorticoid receptor agonist 4Glucocorticoid ReceptorADC CytotoxinADC PayloadTNF-αautoimmuneinflammationInhibitorinhibitorinhibit

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