2. Apoptosis
  3. Apoptosis
  4. Hematoporphyrin monomethyl ether

Hematoporphyrin monomethyl ether 

Cat. No.: HY-134990 Purity: ≥95.0%
SDS COA Handling Instructions

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Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and research of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma.

For research use only. We do not sell to patients.

Hematoporphyrin monomethyl ether Chemical Structure

Hematoporphyrin monomethyl ether Chemical Structure

CAS No. : 148471-91-4

Size Price Stock Quantity
5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 470 In-stock
50 mg USD 750 In-stock
100 mg USD 1180 In-stock
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Based on 1 publication(s) in Google Scholar

Hematoporphyrin monomethyl ether Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Hematoporphyrin monomethyl ether

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and research of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma[1].

In Vitro

Hematoporphyrin monomethyl ether (HMME) is a novel and promising porphyrin-related photosensitizer for photodynamic therapy (PDT). HMME-PDT can induce cell deaththrough both necrosis and apoptosis in HeLa cells. ROS, such as singlet oxygen and hydroxyl radical, generated in HeLa cells play a decisive role in HMME-PDT-induced cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hematoporphyrin monomethyl ether Related Antibodies
Molecular Weight

1225.43

Formula

C70H80N8O12
CAS No.
Appearance

Solid

SMILES

O=C(CCC(C1=N/2)=C(C)C2=C\C3=C(C(C)OC)C(C)=C(/C=C4N=C(C(C)=C\4C(C)O)/C=C5N/C(C(CCC(O)=O)=C\5C)=C\1)N3)O.O=C(CCC(C6=N/7)=C(C)C7=C\C8=C(C(C)O)C(C)=C(/C=C9N=C(C(C)=C\9C(C)OC)/C=C%10N/C(C(CCC(O)=O)=C\%10C)=C\6)N8)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (51.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8160 mL 4.0802 mL 8.1604 mL
5 mM 0.1632 mL 0.8160 mL 1.6321 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (1.70 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (323 KB) HNMR (340 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8160 mL 4.0802 mL 8.1604 mL 20.4010 mL
5 mM 0.1632 mL 0.8160 mL 1.6321 mL 4.0802 mL
10 mM 0.0816 mL 0.4080 mL 0.8160 mL 2.0401 mL
15 mM 0.0544 mL 0.2720 mL 0.5440 mL 1.3601 mL
20 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0201 mL
25 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8160 mL
30 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6800 mL
40 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5100 mL
50 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4080 mL
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Hematoporphyrin monomethyl ether Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hematoporphyrin monomethyl ether148471-91-4ApoptosisporphyrinrelatedphotosensitizerphotodynamictherapyHeLacellsdeathoxygenselectivecancerInhibitorinhibitorinhibit

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