2. Apoptosis
  3. Apoptosis
  4. HS-1793

HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines. HS-1793 induces cell apoptosis.

For research use only. We do not sell to patients.

HS-1793 Chemical Structure

HS-1793 Chemical Structure

CAS No. : 927885-00-5

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10 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

HS-1793 Related Antibodies

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Description

HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines[1]. HS-1793 induces cell apoptosis[2].

Cellular Effect
Cell Line Type Value Description References
MCF-10A IC50
> 100 μM
Compound: HS-1793
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 32485531]
MCF7 IC50
26.3 μM
Compound: HS-1793
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 32485531]
MDA-MB-231 IC50
48.2 μM
Compound: HS-1793
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 32485531]
In Vitro

HS-1793 (0-100 µM; 24 h) suppresses proliferation of MCF-7, MDA-MB-231 and HCT116 cells[1][2].
HS-1793 (0-50 µM; 4 h) inhibits hypoxia-induced HIF-1α protein in MCF-7 and MDA-MB-231 cells unrelated to cell death, downregulates hypoxia-induced VEGF expression, and suppresses hypoxia-induced mRNA expression of VEGF at the transcriptional level[1].
HS-1793 (0-100 µM; 24 h) induces apoptosis, promotes G2/M cell cycle arrest, and inhibits Akt and ERK phosphorylation in HCT116 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HS-1793 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-231 and MCF-10A
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Showed antiproliferation activity with IC50 values of 26.3±3.2, 48.2±4.2 and >100 μM against MCF-7, MDA-MB-231 and MCF-10A, respectively.

Western Blot Analysis[1]

Cell Line: MCF-7, MDA-MB-231
Concentration: 12.5, 25 and 50 μM
Incubation Time: 4 h
Result: Downregulated HIF-1α expression in a concentration-dependent manner in both cell lines.

RT-PCR[1]

Cell Line: MCF-7, MDA-MB-231
Concentration: 12.5, 25 and 50 μM
Incubation Time: 4 h
Result: Downregulated the expression of VEGF mRNA, with the more marked results observed in MDA-MB-231 cells.

Cell Proliferation Assay[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 1, 2 and 4 days
Result: Significantly reduced the cell viability concentration- and time-dependently. Significantly suppressed proliferation of colon cancer cell line HCT116.

Apoptosis Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 24 h
Result: Induced cell apoptosis in a dose-dependent manner. Caused chromatin condensation and fragmentation.

Western Blot Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 24 h
Result: Effectively induced the reduction of pro-caspase-8 and pro-caspase-3 at 100 µM. Activated caspase-8 and caspase-3. Caused the PARP cleavage. Slightly downregulated the level of antiapoptotic protein Bcl-2 at 100 µM. Promoted an increase in the release of cytochrome c from the mitochondria into the cytosol. Decreased the expression of G2/M cell cycle regulatory protein cyclin B1, Cdc2 and Cdc25C. Decreased the level of CDK4 and CDK6. Decreased Akt phosphorylation and reduced total Akt at high-concentration. Decreased the phosphorylation of ERK1/2 without affecting the protein level.

Cell Cycle Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25 and 50 µM
Incubation Time: 24 h
Result: Induced the accumulation of cells in the G2/M phase in a concentration-dependent manner.
In Vivo

HS-1793 (5 and 10 mg/kg; i.p.; twice a week, 4 weeks) significantly inhibits MDA-MB-231 xenograft tumor growth and in a dose-dependent manner and relatively hampers angiogenesis with non-toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old female BALB/c nude mice injected with MDA-MB-231 cells[1]
Dosage: 5 mg/kg and 10 mg/kg (dissolved in PBS containing 0.1% v/v dimethyl sulfoxide (DMSO))
Administration: Intraperitoneal injection, twice a week, 4 weeks
Result: Significantly inhibited MDA-MB-231 xenograft tumor growth in a dose-dependent manner with non-toxicity. Significantly lowered Ki-67 (a proliferation marker) and CD31 expression. Successfully suppressed the expression of HIF-1α and VEGF in tumor tissues.
Molecular Weight

252.26

Formula

C16H12O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (495.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9642 mL 19.8208 mL 39.6416 mL
5 mM 0.7928 mL 3.9642 mL 7.9283 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9642 mL 19.8208 mL 39.6416 mL 99.1041 mL
5 mM 0.7928 mL 3.9642 mL 7.9283 mL 19.8208 mL
10 mM 0.3964 mL 1.9821 mL 3.9642 mL 9.9104 mL
15 mM 0.2643 mL 1.3214 mL 2.6428 mL 6.6069 mL
20 mM 0.1982 mL 0.9910 mL 1.9821 mL 4.9552 mL
25 mM 0.1586 mL 0.7928 mL 1.5857 mL 3.9642 mL
30 mM 0.1321 mL 0.6607 mL 1.3214 mL 3.3035 mL
40 mM 0.0991 mL 0.4955 mL 0.9910 mL 2.4776 mL
50 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
60 mM 0.0661 mL 0.3303 mL 0.6607 mL 1.6517 mL
80 mM 0.0496 mL 0.2478 mL 0.4955 mL 1.2388 mL
100 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL
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HS-1793 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS-1793927885-00-5HS1793HS 1793ApoptosisresveratrolMCF-7MDA-MB-231HIF-1αcolon cancerbreast cancerHCT116VEGFAktERKInhibitorinhibitorinhibit

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