2. Anti-infection
  3. Bacterial
  4. IMPDH2-IN-2

IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent.

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IMPDH2-IN-2 Chemical Structure

IMPDH2-IN-2 Chemical Structure

CAS No. : 1434517-02-8

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Based on 1 publication(s) in Google Scholar

IMPDH2-IN-2 Related Antibodies

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Description

IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent[1].

IC50 & Target

IMPDH[1]
Molecular Weight

428.27

Formula

C21H15Cl2N3O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@H](OC1=CC=CC(Cl)=C1Cl)C(NC2=CC=C(OC(C3=CC=NC=C3)=N4)C4=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (23.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3350 mL 11.6749 mL 23.3498 mL
5 mM 0.4670 mL 2.3350 mL 4.6700 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3350 mL 11.6749 mL 23.3498 mL 58.3744 mL
5 mM 0.4670 mL 2.3350 mL 4.6700 mL 11.6749 mL
10 mM 0.2335 mL 1.1675 mL 2.3350 mL 5.8374 mL
15 mM 0.1557 mL 0.7783 mL 1.5567 mL 3.8916 mL
20 mM 0.1167 mL 0.5837 mL 1.1675 mL 2.9187 mL
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IMPDH2-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMPDH2-IN-21434517-02-8BacterialIMPDHantibacterialanti-cancerlysine acetyltransferaseanti-tuberculosisInhibitorinhibitorinhibit

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