2. Neuronal Signaling Stem Cell/Wnt PI3K/Akt/mTOR Autophagy
  3. Monoamine Oxidase GSK-3 LRRK2
  4. Indazole

Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases.

For research use only. We do not sell to patients.

Indazole Chemical Structure

Indazole Chemical Structure

CAS No. : 271-44-3

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Indazole Related Antibodies

Top Publications Citing Use of Products

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MAO-A MAO-B

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GSK-3 GSK-3α GSK-3β

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].

In Vitro

Indazole compounds possess potential anticancer activity, and indazole-based agents such as, Axitinib (HY-10065) , Lonidamine (HY-B0486) and Pazopanib (HY-10208) have already been used for cancer research, demonstrating indazole compounds as useful templates for the development of novel anticancer agents[1].
Indazoles show potent activities against neurological disorders by inhibiting the monoamine oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich repeat kinase enzyme 2 (LRRK2)[2].
Various natural and synthetic indazole derivatives Nigellicine, Nigellamine, Nigellidine, Zanubrutinib (HY-101474A) and SCH772984 (HY-50846) showes prominent results to cure various gastrointestinal disorders[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Indazole Related Antibodies
Molecular Weight

118.14

Formula

C7H6N2
CAS No.
Appearance

Solid

Color

Light brown to yellow

SMILES

C12=CC=CC=C1NN=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (846.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.4645 mL 42.3227 mL 84.6453 mL
5 mM 1.6929 mL 8.4645 mL 16.9291 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.72%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.4645 mL 42.3227 mL 84.6453 mL 211.6133 mL
5 mM 1.6929 mL 8.4645 mL 16.9291 mL 42.3227 mL
10 mM 0.8465 mL 4.2323 mL 8.4645 mL 21.1613 mL
15 mM 0.5643 mL 2.8215 mL 5.6430 mL 14.1076 mL
20 mM 0.4232 mL 2.1161 mL 4.2323 mL 10.5807 mL
25 mM 0.3386 mL 1.6929 mL 3.3858 mL 8.4645 mL
30 mM 0.2822 mL 1.4108 mL 2.8215 mL 7.0538 mL
40 mM 0.2116 mL 1.0581 mL 2.1161 mL 5.2903 mL
50 mM 0.1693 mL 0.8465 mL 1.6929 mL 4.2323 mL
60 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5269 mL
80 mM 0.1058 mL 0.5290 mL 1.0581 mL 2.6452 mL
100 mM 0.0846 mL 0.4232 mL 0.8465 mL 2.1161 mL
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Indazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indazole271-44-3Monoamine OxidaseGSK-3LRRK2MAOGlycogen synthase kinase-3Glycogen synthase kinase 3Leucine-rich repeat kinase 2cancerneurological disorderscardiovascular diseasesgastrointestinal diseasesisoindazoleParkinson's diseaseAlzheimer's diseaseInhibitorinhibitorinhibit

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