Indazole

Cat. No.: HY-40294 Purity: 99.30%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases.

For research use only. We do not sell to patients.

Indazole Chemical Structure

CAS No. : 271-44-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	USD 30	Get quote	Estimated Time of Arrival: December 31
5 g	USD 100	Get quote	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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GSK-3 GSK-3α GSK-3β

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Indazole compounds possess potential anticancer activity, and indazole-based agents such as, Axitinib (HY-10065) , Lonidamine (HY-B0486) and Pazopanib (HY-10208) have already been used for cancer research, demonstrating indazole compounds as useful templates for the development of novel anticancer agents^[1].
Indazoles show potent activities against neurological disorders by inhibiting the monoamine oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich repeat kinase enzyme 2 (LRRK2)^[2].
Various natural and synthetic indazole derivatives Nigellicine, Nigellamine, Nigellidine, Zanubrutinib (HY-101474A) and SCH772984 (HY-50846) showes prominent results to cure various gastrointestinal disorders^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

118.14

Formula

C₇H₆N₂

CAS No.

271-44-3

Appearance

Solid

Color

Light brown to yellow

SMILES

C12=CC=CC=C1NN=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (846.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.4645 mL	42.3227 mL	84.6453 mL
5 mM	1.6929 mL	8.4645 mL	16.9291 mL
10 mM	0.8465 mL	4.2323 mL	8.4645 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Shang C, et al. The Anticancer Activity of Indazole Compounds: A Mini Review. Curr Top Med Chem. 2021;21(5):363-376. [Content Brief]

[2]. Pal D, et al. Importance of Indazole against Neurological Disorders. Curr Top Med Chem. 2022;22(14):1136-1151. [Content Brief]

[3]. Uppulapu SK, et al. Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives. Curr Top Med Chem. 2022;22(14):1177-1188. [Content Brief]

[4]. Saha S, et al. Indazole Derivatives Effective against Gastrointestinal Diseases. Curr Top Med Chem. 2022;22(14):1189-1214. [Content Brief]

[5]. Qin J, et al. Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications. Anticancer Agents Med Chem. 2021;21(7):839-860. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.4645 mL	42.3227 mL	84.6453 mL	211.6133 mL
	5 mM	1.6929 mL	8.4645 mL	16.9291 mL	42.3227 mL
	10 mM	0.8465 mL	4.2323 mL	8.4645 mL	21.1613 mL
	15 mM	0.5643 mL	2.8215 mL	5.6430 mL	14.1076 mL
	20 mM	0.4232 mL	2.1161 mL	4.2323 mL	10.5807 mL
	25 mM	0.3386 mL	1.6929 mL	3.3858 mL	8.4645 mL
	30 mM	0.2822 mL	1.4108 mL	2.8215 mL	7.0538 mL
	40 mM	0.2116 mL	1.0581 mL	2.1161 mL	5.2903 mL
	50 mM	0.1693 mL	0.8465 mL	1.6929 mL	4.2323 mL
	60 mM	0.1411 mL	0.7054 mL	1.4108 mL	3.5269 mL
	80 mM	0.1058 mL	0.5290 mL	1.0581 mL	2.6452 mL
	100 mM	0.0846 mL	0.4232 mL	0.8465 mL	2.1161 mL

Indazole Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indazole271-44-3Monoamine OxidaseGSK-3LRRK2MAOGlycogen synthase kinase-3Glycogen synthase kinase 3Leucine-rich repeat kinase 2cancerneurological disorderscardiovascular diseasesgastrointestinal diseasesisoindazoleParkinson's diseaseAlzheimer's diseaseInhibitorinhibitorinhibit

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