Isovalerylcarnitine chloride

Name: Isovalerylcarnitine chloride
Brand: MedChemExpress
SKU: HY-145542
Rating: 4.5 (1 reviews)

Cat. No.: HY-145542 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca²⁺-dependent proteinase (calpain) of human neutrophils.

For research use only. We do not sell to patients.

Isovalerylcarnitine chloride Chemical Structure

CAS No. : 139144-12-0

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5 mg	USD 32	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 288	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Isovalerylcarnitine chloride:

Isovalerylcarnitine In-stock
Isovalerylcarnitine-d₃ chloride Get quote
Isovalerylcarnitine-d₉ chloride Get quote

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Biological Activity
Purity & Documentation
References
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Description

Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca²⁺-dependent proteinase (calpain) of human neutrophils^[1].

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

281.78

Formula

C₁₂H₂₄ClNO₄

CAS No.

139144-12-0

Appearance

Solid

Color

White to off-white

SMILES

CC(C)CC(O[C@H](CC(O)=O)C[N+](C)(C)C)=O.[Cl-]

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (354.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5489 mL	17.7443 mL	35.4887 mL
5 mM	0.7098 mL	3.5489 mL	7.0977 mL
10 mM	0.3549 mL	1.7744 mL	3.5489 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (250 KB)

Handling Instructions (2659 KB)

References

[1]. Pontremoli S, et al. Isovalerylcarnitine is a specific activator of calpain of human neutrophils. Biochem Biophys Res Commun. 1987 Nov 13;148(3):1189-95. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5489 mL	17.7443 mL	35.4887 mL	88.7217 mL
	5 mM	0.7098 mL	3.5489 mL	7.0977 mL	17.7443 mL
	10 mM	0.3549 mL	1.7744 mL	3.5489 mL	8.8722 mL
	15 mM	0.2366 mL	1.1830 mL	2.3659 mL	5.9148 mL
	20 mM	0.1774 mL	0.8872 mL	1.7744 mL	4.4361 mL
	25 mM	0.1420 mL	0.7098 mL	1.4195 mL	3.5489 mL
	30 mM	0.1183 mL	0.5915 mL	1.1830 mL	2.9574 mL
	40 mM	0.0887 mL	0.4436 mL	0.8872 mL	2.2180 mL
	50 mM	0.0710 mL	0.3549 mL	0.7098 mL	1.7744 mL
	60 mM	0.0591 mL	0.2957 mL	0.5915 mL	1.4787 mL
	80 mM	0.0444 mL	0.2218 mL	0.4436 mL	1.1090 mL
	100 mM	0.0355 mL	0.1774 mL	0.3549 mL	0.8872 mL