2. Epigenetics
  3. Histone Demethylase
  4. JMJD6-IN-1

JMJD6-IN-1 (Compound 1-3) is a JMJD6 inhibitor, with an inhibition rate of 82% at 10 μM. JMJD6-IN-1 inhibits MCF-7 and HCC4006 cell proliferation with IC50s of 19.2 μM and 25.2 μM. JMJD6-IN-1 can be used for research of cancers.

For research use only. We do not sell to patients.

JMJD6-IN-1 Chemical Structure

JMJD6-IN-1 Chemical Structure

CAS No. : 899548-78-8

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1 mg USD 60 In-stock
5 mg USD 130 In-stock
10 mg USD 200 In-stock
25 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

JMJD6-IN-1 Related Antibodies

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Description

JMJD6-IN-1 (Compound 1-3) is a JMJD6 inhibitor, with an inhibition rate of 82% at 10 μM. JMJD6-IN-1 inhibits MCF-7 and HCC4006 cell proliferation with IC50s of 19.2 μM and 25.2 μM. JMJD6-IN-1 can be used for research of cancers[1].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
2.44 μM
Compound: WL12
Inhibition of JMJD6 in human HeLa cells assessed as decrease in cell proliferation measured after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay
Inhibition of JMJD6 in human HeLa cells assessed as decrease in cell proliferation measured after 72 hrs by CellTiter 96 AQueous one solution cell proliferation assay
[PMID: 31857835]
Molecular Weight

277.28

Formula

C16H11N3O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C(N2)=NC3=C2C=NC=C3)=CC4=CC(C)=CC=C4O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMF : 10 mg/mL (36.06 mM; Need ultrasonic)

DMSO : 5 mg/mL (18.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6065 mL 18.0323 mL 36.0646 mL
5 mM 0.7213 mL 3.6065 mL 7.2129 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.69%

SDS (392 KB)

COA (250 KB) HNMR (258 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 3.6065 mL 18.0323 mL 36.0646 mL 90.1616 mL
5 mM 0.7213 mL 3.6065 mL 7.2129 mL 18.0323 mL
10 mM 0.3606 mL 1.8032 mL 3.6065 mL 9.0162 mL
15 mM 0.2404 mL 1.2022 mL 2.4043 mL 6.0108 mL
DMF 20 mM 0.1803 mL 0.9016 mL 1.8032 mL 4.5081 mL
25 mM 0.1443 mL 0.7213 mL 1.4426 mL 3.6065 mL
30 mM 0.1202 mL 0.6011 mL 1.2022 mL 3.0054 mL
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JMJD6-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JMJD6-IN-1899548-78-8Histone DemethylaseJMJD6 inhibitorMCF-7HCC4006cancertumorInhibitorinhibitorinhibit

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