Parishin E

Name: Parishin E
Brand: MedChemExpress
SKU: HY-N2126
Rating: 4.5 (1 reviews)

Cat. No.: HY-N2126 Purity: 99.09%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Parishin E, a parishin derivative isolated from Gastrodia elata, may have antioxidant property.

For research use only. We do not sell to patients.

Parishin E Chemical Structure

CAS No. : 952068-57-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Parishin E (Standard) Get quote

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Description

Parishin E, a parishin derivative isolated from Gastrodia elata, may have antioxidant property^[1].

Molecular Weight

460.39

Formula

C₁₉H₂₄O₁₃

CAS No.

952068-57-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(COC(CC(O)(C(O)=O)CC(O)=O)=O)C=C2

Structure Classification

Phenols

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (217.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1721 mL	10.8604 mL	21.7207 mL
5 mM	0.4344 mL	2.1721 mL	4.3441 mL
10 mM	0.2172 mL	1.0860 mL	2.1721 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.09%

Select Batch:

Data Sheet (270 KB) SDS (392 KB)

COA (246 KB) HNMR (274 KB) LCMS (261 KB)

Handling Instructions (2659 KB)

References

[1]. Liu J, et al. An Optimized and Sensitive Pharmacokinetic Quantitative Method of Investigating Gastrodin, Parishin, and Parishin B, C and E in Beagle Dog Plasma using LC-MS/MS after Intragastric Administration of Tall Gastrodia Capsules. Molecules. 2017 Nov 10;22(11). [Content Brief]

[2]. Kim DW, et al. Comparison of Bioactive Compounds and Antioxidant Activities of Maclura tricuspidata Fruit Extracts at Different Maturity Stages. Molecules. 2019 Feb 4;24(3). [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1721 mL	10.8604 mL	21.7207 mL	54.3018 mL
	5 mM	0.4344 mL	2.1721 mL	4.3441 mL	10.8604 mL
	10 mM	0.2172 mL	1.0860 mL	2.1721 mL	5.4302 mL
	15 mM	0.1448 mL	0.7240 mL	1.4480 mL	3.6201 mL
	20 mM	0.1086 mL	0.5430 mL	1.0860 mL	2.7151 mL
	25 mM	0.0869 mL	0.4344 mL	0.8688 mL	2.1721 mL
	30 mM	0.0724 mL	0.3620 mL	0.7240 mL	1.8101 mL
	40 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3575 mL
	50 mM	0.0434 mL	0.2172 mL	0.4344 mL	1.0860 mL
	60 mM	0.0362 mL	0.1810 mL	0.3620 mL	0.9050 mL
	80 mM	0.0272 mL	0.1358 mL	0.2715 mL	0.6788 mL
	100 mM	0.0217 mL	0.1086 mL	0.2172 mL	0.5430 mL

Parishin E Related Classifications

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Keywords:

Parishin E952068-57-4OthersInhibitorinhibitorinhibit

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Parishin E

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Other Forms of Parishin E:

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Complete Stock Solution Preparation Table

Parishin E Related Classifications

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