1. Apoptosis
  2. c-Myc
  3. JY-3-094

JY-3-094 is a Myc inhibitor that inhibits Myc-Max heterodimer formation (IC50: 33 μM).

For research use only. We do not sell to patients.

JY-3-094 Chemical Structure

JY-3-094 Chemical Structure

CAS No. : 389076-27-1

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Based on 1 publication(s) in Google Scholar

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Description

JY-3-094 is a Myc inhibitor that inhibits Myc-Max heterodimer formation (IC50: 33 μM)[1].

IC50 & Target

IC50: 33 μM (Myc-Max)[1]

Cellular Effect
Cell Line Type Value Description References
Daudi IC50
56 μM
Compound: 3q, JY-3-094
Cytotoxicity against human Daudi cells assessed as growth inhibition after 3 to 5 days by MTT assay
Cytotoxicity against human Daudi cells assessed as growth inhibition after 3 to 5 days by MTT assay
[PMID: 23177256]
HL-60 IC50
184 μM
Compound: 3q, JY-3-094
Cytotoxicity against human HL60 cells assessed as growth inhibition after 3 to 5 days by MTT assay
Cytotoxicity against human HL60 cells assessed as growth inhibition after 3 to 5 days by MTT assay
[PMID: 23177256]
Molecular Weight

300.23

Formula

C13H8N4O5

CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=C(O)C1=CC=C(NC2=CC=C([N+]([O-])=O)C3=NON=C32)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (83.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3308 mL 16.6539 mL 33.3078 mL
5 mM 0.6662 mL 3.3308 mL 6.6616 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3308 mL 16.6539 mL 33.3078 mL 83.2695 mL
5 mM 0.6662 mL 3.3308 mL 6.6616 mL 16.6539 mL
10 mM 0.3331 mL 1.6654 mL 3.3308 mL 8.3269 mL
15 mM 0.2221 mL 1.1103 mL 2.2205 mL 5.5513 mL
20 mM 0.1665 mL 0.8327 mL 1.6654 mL 4.1635 mL
25 mM 0.1332 mL 0.6662 mL 1.3323 mL 3.3308 mL
30 mM 0.1110 mL 0.5551 mL 1.1103 mL 2.7756 mL
40 mM 0.0833 mL 0.4163 mL 0.8327 mL 2.0817 mL
50 mM 0.0666 mL 0.3331 mL 0.6662 mL 1.6654 mL
60 mM 0.0555 mL 0.2776 mL 0.5551 mL 1.3878 mL
80 mM 0.0416 mL 0.2082 mL 0.4163 mL 1.0409 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JY-3-094
Cat. No.:
HY-125978
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