2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D inhibitor 3 TFA

KRAS G12D inhibitor 3 TFA is a KRAS G12D inhibitor with an IC50 of <500 nM. KRAS G12D inhibitor 3 TFA has antitumor effects (WO2022002102A1; compound 146). KRAS G12D inhibitor 3 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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KRAS G12D inhibitor 3 TFA Chemical Structure

KRAS G12D inhibitor 3 TFA Chemical Structure

CAS No. : 2757095-12-6

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5 mg USD 480 In-stock
10 mg USD 770 In-stock
25 mg USD 1540 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

KRAS G12D inhibitor 3 TFA is a KRAS G12D inhibitor with an IC50 of <500 nM. KRAS G12D inhibitor 3 TFA has antitumor effects (WO2022002102A1; compound 146)[1]. KRAS G12D inhibitor 3 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

KRas G12D

<500 nM (IC50)

Molecular Weight

748.11

Formula

C36H32ClF6N5O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C#CC1=C(C=CC2=C1C(C3=C(C4=C(C(N5CC6CCC(N6)C5)=NC(OC[C@@]78CCCN7C[C@@H](C8)F)=N4)C=C3Cl)F)=CC(O)=C2)F.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (133.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3367 mL 6.6835 mL 13.3670 mL
5 mM 0.2673 mL 1.3367 mL 2.6734 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3367 mL 6.6835 mL 13.3670 mL 33.4175 mL
5 mM 0.2673 mL 1.3367 mL 2.6734 mL 6.6835 mL
10 mM 0.1337 mL 0.6684 mL 1.3367 mL 3.3418 mL
15 mM 0.0891 mL 0.4456 mL 0.8911 mL 2.2278 mL
20 mM 0.0668 mL 0.3342 mL 0.6684 mL 1.6709 mL
25 mM 0.0535 mL 0.2673 mL 0.5347 mL 1.3367 mL
30 mM 0.0446 mL 0.2228 mL 0.4456 mL 1.1139 mL
40 mM 0.0334 mL 0.1671 mL 0.3342 mL 0.8354 mL
50 mM 0.0267 mL 0.1337 mL 0.2673 mL 0.6684 mL
60 mM 0.0223 mL 0.1114 mL 0.2228 mL 0.5570 mL
80 mM 0.0167 mL 0.0835 mL 0.1671 mL 0.4177 mL
100 mM 0.0134 mL 0.0668 mL 0.1337 mL 0.3342 mL
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KRAS G12D inhibitor 3 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12D inhibitor 32757095-12-6RasKRAS G12D inhibitorantitumor effectsInhibitorinhibitorinhibit

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