2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. KYN-101

KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity.

For research use only. We do not sell to patients.

KYN-101 Chemical Structure

KYN-101 Chemical Structure

CAS No. : 2247950-73-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 198 In-stock
Solution
10 mM * 1 mL in DMSO USD 198 In-stock
Solid
5 mg USD 180 In-stock
10 mg USD 280 In-stock
25 mg USD 520 In-stock
50 mg USD 800 In-stock
100 mg USD 1200 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

KYN-101 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity[1].

In Vitro

KYN-101 (0.5, 1 µM; 24 h) decreases the CYP1A1 mRNA expression in IDOhigh samples[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KYN-101 Related Antibodies
In Vivo

KYN-101 (10 mg/kg; p.o.; daily for 12 days) shows anti-cancer activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice)[1]
Dosage: 10 mg/kg
Administration: P.o.; daily for 12 days
Result: Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.
Molecular Weight

386.42

Formula

C22H19FN6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=C2N=C(C3=CC(F)=CN=C3)C=C(NCCC4=CNC5=C4C=CC=C5)N2N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (258.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5879 mL 12.9393 mL 25.8786 mL
5 mM 0.5176 mL 2.5879 mL 5.1757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5879 mL 12.9393 mL 25.8786 mL 64.6964 mL
5 mM 0.5176 mL 2.5879 mL 5.1757 mL 12.9393 mL
10 mM 0.2588 mL 1.2939 mL 2.5879 mL 6.4696 mL
15 mM 0.1725 mL 0.8626 mL 1.7252 mL 4.3131 mL
20 mM 0.1294 mL 0.6470 mL 1.2939 mL 3.2348 mL
25 mM 0.1035 mL 0.5176 mL 1.0351 mL 2.5879 mL
30 mM 0.0863 mL 0.4313 mL 0.8626 mL 2.1565 mL
40 mM 0.0647 mL 0.3235 mL 0.6470 mL 1.6174 mL
50 mM 0.0518 mL 0.2588 mL 0.5176 mL 1.2939 mL
60 mM 0.0431 mL 0.2157 mL 0.4313 mL 1.0783 mL
80 mM 0.0323 mL 0.1617 mL 0.3235 mL 0.8087 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6470 mL
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KYN-101 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KYN-1012247950-73-6KYN101KYN 101Aryl Hydrocarbon ReceptorAhRCYP1A1 mRNAorally activeanti-cancerindoleamine 2,3-dioxygenase (IDO)Inhibitorinhibitorinhibit

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