2. Anti-infection
  3. Bacterial Antibiotic
  4. Leucomycin

Leucomycin (Kitasamycin) is an orally active macrolide antibiotic produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses.

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Leucomycin Chemical Structure

Leucomycin Chemical Structure

CAS No. : 1392-21-8

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Based on 1 publication(s) in Google Scholar

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Leucomycin Related Antibodies

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Description

Leucomycin (Kitasamycin) is an orally active macrolide antibiotic produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses[1][2][3][4][5][6][7].

IC50 & Target

Macrolide

 

In Vitro

Leucomycin (0.1-100 μg/mL, 0-8 h) demonstrates weak bactericidal activities against Staphylococci similar to Maridomycin in vitro[6].

Antibacterial spectra of Leucomycin[6]

Organism Staphylococcus aureus FDA209 P Streptococcuspyogenes E-14 Streptococcus viridans Diplococcus pneumoniae type I Corynebacterium diphtheriae Bacillus subtilis Neisseria gonorrhoeae
MIC in μg/mL1.56 0.78 0.39 0.39 0.39 1.56 0.78

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leucomycin Related Antibodies
In Vivo

Leucomycin ( 29.8-446 mg/kg, s.c., i.p., i.v., p.o., a single dose for 7 days) has therapeutic activities on S. aureus 308 A-1, S. pyogenes E-14 and D. pneumoniae type I infection in mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice infected by S. aureus 308 A-1, S. pyogenes E-14 and D. pneumoniae type I[6]
Dosage: 29.8-446 mg/kg
Administration: s.c., i.p., i.v., p.o., a single dose for 7 days
Result: Was relatively high in the therapeutic activity of staphylococcal or streptococcal infection compared to maridomycin in oral route.
Was approximately equal in the therapeutic activity of diplococcal infection compared to maridomycin in oral route.
Showed the same therapeutic activity as Maridomycin against Gram-positive bacterial infections in subcutaneous, intraperitoneal and intravenous administration.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Leucomycin]
Structure Classification
Initial Source

Streptomyces kitasatoensis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.75 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.75 mg/mL; Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.75 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
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Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

SDS (392 KB)

COA (242 KB)

Handling Instructions (2659 KB)
References
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Leucomycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leucomycin1392-21-8KitasamycinBacterialAntibioticorally activeantibioticStreptomyces kitasatoensisantibacterial activitygram-positive and gram-negative bacteriaInhibitorinhibitorinhibit

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