2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Bacterial DNA/RNA Synthesis Topoisomerase Orthopoxvirus
  4. Levofloxacin hydrochloride

Levofloxacin hydrochloride  (Synonyms: (-)-Ofloxacin hydrochloride)

Cat. No.: HY-B0330B Purity: ≥98.0%
COA Handling Instructions

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Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity.

For research use only. We do not sell to patients.

Levofloxacin hydrochloride Chemical Structure

Levofloxacin hydrochloride Chemical Structure

CAS No. : 177325-13-2

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Based on 11 publication(s) in Google Scholar

Other Forms of Levofloxacin hydrochloride:

Levofloxacin hydrochloride Related Antibodies

Top Publications Citing Use of Products

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

View All Topoisomerase Isoform Specific Products:

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Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

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Description

Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity[1][2][3][4][5].

IC50 & Target

TOPO IV

 

Clinical Trial
Molecular Weight

397.83

Formula

C18H21ClFN3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (50.27 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5136 mL 12.5682 mL 25.1364 mL
5 mM 0.5027 mL 2.5136 mL 5.0273 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5136 mL 12.5682 mL 25.1364 mL 62.8409 mL
5 mM 0.5027 mL 2.5136 mL 5.0273 mL 12.5682 mL
10 mM 0.2514 mL 1.2568 mL 2.5136 mL 6.2841 mL
15 mM 0.1676 mL 0.8379 mL 1.6758 mL 4.1894 mL
20 mM 0.1257 mL 0.6284 mL 1.2568 mL 3.1420 mL
25 mM 0.1005 mL 0.5027 mL 1.0055 mL 2.5136 mL
30 mM 0.0838 mL 0.4189 mL 0.8379 mL 2.0947 mL
40 mM 0.0628 mL 0.3142 mL 0.6284 mL 1.5710 mL
50 mM 0.0503 mL 0.2514 mL 0.5027 mL 1.2568 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Levofloxacin hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levofloxacin177325-13-2(-)-OfloxacinAntibioticBacterialDNA/RNA SynthesisTopoisomeraseOrthopoxviruschronic periodontitisairway inflammationBK ViremiaDNA gyraseInhibitorinhibitorinhibit

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